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Erosive and inflammatory joint changes in hereditary hemochromatosis arthropathy detected by low-field magnetic resonance imaging

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Abstract

The aim of the article is to describe and characterize the hemochromatosis arthropathy of the hand by low-field MRI in symptomatic and asymptomatic patients. Forty-nine patients with hereditary hemochromatosis (37 with and twelve without arthropathy) were examined clinically and by low-field MRI of the hands. The examination showed heterogeneous degenerative and inflammatory joint changes such as erosions (in 84 % of all symptomatic patients), synovitis (77 %), bone marrow edema (38 %), subchondral cysts (30 %), tenosynovitis (30 %), joint space narrowing (73 %) and osteophytes (59 %) including hook-shaped osteophytes at MCP joints (32 %). Mild joint changes were also seen in a lower percentage of asymptomatic patients. This is the first larger study addressing the joint changes of the hand in hereditary hemochromatosis using low-field MRI. Our study emphasizes the inflammatory and destructive character of the arthropathy besides the well-known degenerative joint changes described in conventional X-ray. The impact of joint changes in asymptomatic patients deserves further investigation.

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  1. Martin-Luther-University Hospital Halle (Saale), Halle, Saxony-Anhalt, Germany

    Katja Frenzen, Christoph Schäfer & Gernot Keyßer

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  1. Katja Frenzen
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  2. Christoph Schäfer
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Correspondence to Katja Frenzen.

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Frenzen, K., Schäfer, C. & Keyßer, G. Erosive and inflammatory joint changes in hereditary hemochromatosis arthropathy detected by low-field magnetic resonance imaging. Rheumatol Int 33, 2061–2067 (2013). https://doi.org/10.1007/s00296-013-2694-3

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