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A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety

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Abstract

Tripterygium wilfordii Hook F (TwHF) is a Chinese herb with immunosuppressive effects and an established history of use in the treatment of rheumatoid arthritis (RA). Numerous preclinical studies have demonstrated that the extracts from the root of TwHF inhibit the expression of proinflammatory cytokines, proinflammatory mediators, adhesion molecules, and matrix metalloproteinases by macrophages, lymphocytes, synovial fibroblasts, and chondrocytes. TwHF also induces apoptosis in lymphocytes and synovial fibroblasts and inhibits their proliferation. Except numerous uncontrolled clinical trials, there are some prospective, double-blind, randomized, and placebo/sulfasalazine-controlled trials, also demonstrating greater improvement in RA disease activity by TwHF extract than placebo/sulfasalazine. Radiographic progression in RA may also be retarded by TwHF. Therefore, the immunosuppressive, cartilage protective, and anti-inflammatory effects of TwHF extracts are well demonstrated, and TwHF extract is an alternative disease modifying anti-rheumatic drug (DMARD) for the patients with RA refractory to conventional therapy.

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Acknowledgments

This study was supported in part by the grants from National Natural Science Foundation of China (No. 30972729) and Shanghai Natural Science Foundation (No. 09ZR1410700).

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  1. Department of Rheumatology & Immunology, Changzheng Hospital, Second Military Medical University, Shanghai, China

    Jun Bao

  2. Department of Rheumatology & Immunology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, 200433, Shanghai, People’s Republic of China

    Sheng-Ming Dai

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  1. Jun Bao
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Correspondence to Sheng-Ming Dai.

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Bao, J., Dai, SM. A Chinese herb Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: mechanism, efficacy, and safety. Rheumatol Int 31, 1123–1129 (2011). https://doi.org/10.1007/s00296-011-1841-y

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