Rheumatology International

, Volume 32, Issue 4, pp 991–995

The status of serum vitamin D in patients with rheumatoid arthritis and undifferentiated inflammatory arthritis compared with controls

  • Behzad Heidari
  • Karimollah Hajian-Tilaki
  • Parnaz Heidari
Original Article

DOI: 10.1007/s00296-010-1736-3

Cite this article as:
Heidari, B., Hajian-Tilaki, K. & Heidari, P. Rheumatol Int (2012) 32: 991. doi:10.1007/s00296-010-1736-3


Inadequate vitamin D may be involved in the pathogenesis and or progression of several disorders, including connective tissue diseases. To determine the status of vitamin D in different stages of inflammatory arthritis, the levels of vitamin D in established rheumatoid arthritis (RA) and undifferentiated inflammatory arthritis (UIA) were compared with controls. Patients with RA and UIA entered the study. Serum 25-hydroxyvitamin D (25-OHD) was measured by ELISA method, and concentrations less than 20 ng/ml were considered as deficient levels. In statistical analysis, the Mann–Whitney U test was used for comparing differences between groups and logistic regression analysis with calculation of adjusted odds ratio (OR) was used to determine the association between serum 25-OHD deficiency and disease condition. A total of 108 RA, 39 UIA, and 239 controls were studied. There were no significant differences in mean serum 25-OHD level and frequency of serum 25-OHD deficiency between RA and controls (37 ± 37.7 vs. 33.2 ± 28.6 ng/ml, P = 0.96). But the mean serum 25-OHD level in UIA was significantly lower than in the controls (25.1 ± 23.9 vs. 33.2 ± 28.6 ng ml, P = 0.04). A significant positive association was observed between serum 25-OHD deficiency and UIA (56.4% vs. 35.5%, OR = 2.34, 95% CI, 1.18–4.65, P = 0.021) which remained significant after adjustment for sex and age (adjusted OR = 2.24, 95% CI, 1.01–4.55, P = 0.026). Whereas the association between serum 25-OHD deficiency and RA did not reach statistical significance (40.7% vs. 35.5%, OR = 1.24, 95% CI, 0.78–1.99). These findings indicate higher serum vitamin D deficiency in patients with ongoing arthritis rather than established arthritis. Respecting to deleterious effects of vitamin D deficiency on immune system and progressive nature of UIA, a significant proportion of high risk UIA can be recognized by serum 25-OHD determination.


Vitamin D deficiencyRheumatoid arthritisUndifferentiated inflammatory arthritisAssociation

Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Behzad Heidari
    • 1
  • Karimollah Hajian-Tilaki
    • 2
  • Parnaz Heidari
    • 3
  1. 1.Department of Internal Medicine, Division of Rheumatology, Rouhani HospitalBabol University of Medical ScienceBabolIran
  2. 2.Department of Social MedicineBabol University of Medical SciencesBabolIran
  3. 3.Faculti of MedicineTehran Azad University of Medical SciencesTehranIran