Recent insights into Candida albicans biofilm resistance mechanisms
Like other microorganisms, free-living Candida albicans is mainly present in a three-dimensional multicellular structure, which is called a biofilm, rather than in a planktonic form. Candida albicans biofilms can be isolated from both abiotic and biotic surfaces at various locations within the host. As the number of abiotic implants, mainly bloodstream and urinary catheters, has been increasing, the number of biofilm-associated bloodstream or urogenital tract infections is also strongly increasing resulting in a raise in mortality. Cells within a biofilm structure show a reduced susceptibility to specific commonly used antifungals and, in addition, it has recently been shown that such cells are less sensitive to killing by components of our immune system. In this review, we summarize the most important insights in the mechanisms underlying biofilm-associated antifungal drug resistance and immune evasion strategies, focusing on the most recent advances in this area of research.
- Recent insights into Candida albicans biofilm resistance mechanisms
- Open Access
- Available under Open Access This content is freely available online to anyone, anywhere at any time.
Volume 59, Issue 4 , pp 251-264
- Cover Date
- Print ISSN
- Online ISSN
- Springer Berlin Heidelberg
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- Candida albicans
- Drug resistance
- Host immune response
- Industry Sectors