Abstract
The objective of this study was to develop an effective, potential wound dressing consisting of a blended hydrogel of polyvinyl alcohol (PVA) and tannic acid (TA). PVA is known for its biocompatibility and hydrophilicity, and TA is known for being a natural compound which can serve as a cross-linking agent and a therapeutic agent. To prepare the PVA/TA hydrogel, a blended aqueous solution of PVA and TA was processed through three cycles of freezing at −20 ± 3 °C for 18 h followed by thawing at 25 °C for 6 h. Consequently, the PVA/TA hydrogel was successfully prepared through the freeze-thawing process. In an investigation of the hydrogel, it was found that the mechanical strength and hardness increased and that the moisture content decreased as the TA concentration was increased. Moreover, the PVA/TA hydrogel showed excellent antibacterial ability (>99.99%) and antioxidant ability (>92%).
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Okabayashi R, Nakamura M, Okabayashi T, Tanaka Y, Nagai A, Yamashita K (2009) Efficacy of polarized hydroxyapatite and silk fibroin composite dressing gel on epidermal recovery from full-thickness skin wounds. J Biomed Mater Res Part B 90:641–646. doi:10.1002/jbm.b.31329
Haque ANMA, Hannan M, Rana MM (2015) Compatibility analysis of reactive dyes by exhaustion-fixation and adsorption isotherm on knitted cotton fabric. FATE 2:3. doi:10.1186/s40691-015-0026-9
Zhang D, Zhou W, Wei B, Wang X, Tang R, Nie J, Wang J (2015) Carboxyl-modified poly(vinyl alcohol)-crosslinked chitosan hydrogel films for potential wound dressing. Carbohydr Polym 125:189–199. doi:10.1016/j.carbpol.2015.02.034
Paddle-Ledinek JE, Nasa Z, Cleland HJ (2006) Effect of different wound dressings on cell viability and proliferation. Plast Reconstr Surg 117(7 Suppl):110S–118S (discussion 119S–120S). doi:10.1097/01.prs.0000225439.39352.ce
Mhessn RJ, Abd-Alredha L, Al-Rubaie R, Aziz AFK (2011) Preparation of tannin based hydrogel for biological application. E J Chem 8:1638–1643. doi:10.1155/2011/763295
Purna SK, Babu M (2000) Collagen based dressings—a review. Burns 26:54–62. doi:10.1016/S0305-4179(99)00103-5
Hong KH, Sun G (2010) Photoactive antimicrobial PVA hydrogel prepared by freeze-thawing process for wound dressing. J Appl Polym Sci 116:2418–2424. doi:10.1002/app.31827
Kamoun EA, Chen X, Eldin MSM, Kenawy ES (2015) Crosslinked poly(vinyl alcohol) hydrogels for wound dressing applications: a review of remarkably blended polymers. Arab J Chem 8:1–14. doi:10.1016/j.arabjc.2014.07.005
Sionkowska A, Kaczmarek B, Gnatowska M, Kowalonek J (2015) The influence of UV-irradiation on chitosan modified by the tannic acid addition. J Photochem Photobiol B Biol 148:333–339. doi:10.1016/j.jphotobiol.2015.03.028
Brazdaru L, Micutz M, Staicu T, Albu M, Sulea D, Leca M (2015) Structural and rheological properties of collagen hydrogels containing tannic acid and chlorhexidine digluconate intended for topical applications. C R Chim 18:160–169. doi:10.1016/j.crci.2014.07.007
Orlowski P, Krzyzowska M, Zdanowski R, Winnicka A, Nowakowska J, Stankiewicz W, Tomaszewska E, Celichowski G, Grobelny J (2013) Assessment of in vitro cellular responses of monocytes and keratinocytes to tannic acid modified silver nanoparticles. Toxicol Vitro 27:1798–1808. doi:10.1016/j.tiv.2013.05.010
Afshari MJ, Sheikh N, Afarideh H (2015) PVA/CM-chitosan/honey hydrogels prepared by using the combined technique of irradiation followed by freeze-thawing. Radiat Phys Chem 113:28–35. doi:10.1016/j.radphyschem.2015.04.023
Qi X, Hu X, Wei W, Yu H, Li J, Zhang J, Dong W (2015) Investigation of Salecan/poly(vinyl alcohol) hydrogels prepared by freeze/thaw method. Carbohydr Polym 118:60–69. doi:10.1016/j.carbpol.2014.11.021
Kim TH, An DB, Oh SH, Kang MK, Song HH, Lee JH (2015) Creating stiffness gradient polyvinyl alcohol hydrogel using a simple gradual freezing-thawing method to investigate stem cell differentiation behaviors. Biomaterials 40:51–60. doi:10.1016/j.biomaterials.2014.11.017
Hassan CM, Peppas NA (2000) Structure and morphology of freeze/thawed PVA hydrogels. Macromolecules 33:2472–2479. doi:10.1021/ma9907587
Han J, Weng X, Bi K (2008) Antioxidants from a Chinese medicinal herb—Lithospermum erythrorhizon. Food Chem 106:2–10. doi:10.1016/j.foodchem.2007.01.031
Alger MSM (1997) Polymer science dictionary. Springer, London, p 152
Li H, Zhang W, Xu W, Zhang X (2000) Hydrogen bonding governs the elastic properties of poly(vinyl alcohol) in water: single-molecule force spectroscopic studies of PVA by AFM. Macromolecules 33:465–469. doi:10.1021/ma990878e
Lee H, Mensire R, Cohen RE, Rubner MF (2012) Strategies for hydrogen bonding based layer-by-layer assembly of poly(vinyl alcohol) with weak polyacids. Macromolecules 45:347–355. doi:10.1021/ma202092w
Stockton WB, Rubner MF (1997) Molecular-level processing of conjugated polymers. 4. Layer-by-layer manipulation of polyaniline via hydrogen-bonding interactions. Macromolecules 30:2717–2725. doi:10.1021/ma9700486
Kozlovskaya V, Kharlampieva E, Drachuk I, Cheng D, Tsukruk VV (2010) Responsive microcapsule reactors based on hydrogen-bonded tannic acid layer-by-layer assemblies. Soft Matter 6:3596–3608. doi:10.1039/B927369G
Caitlin S (2014) Hydrogen-bonded layer-by-layer assembly of poly(vinyl alcohol) and tannic acid. Massachusetts Institute of Technology, Cambridge, p 14
Barrett AH, Kaletunc G (1998) Quantitative description of fracturability changes in puffed corn extrudates affected by sorption of low levels of moisture. Cereal Chem 75:695–698. doi:10.1094/CCHEM.1998.75.5.695
Zhou L, Chen M, Tian L, Guan Y, Zhang Y (2013) Release of polyphenolic drugs from dynamically bonded layer-by-layer films. ACS Appl Mater Interfaces 5:3541–3548. doi:10.1021/am4008787
Pawde SM, Deshmukh K (2008) Characterization of polyvinyl alcohol/gelatin blend hydrogel films for biomedical applications. J Appl Polym Sci 109:3431–3437. doi:10.1002/app.28454
Pavia DL, Lampman GM, Kriz GS (1996) Introduction to spectroscopy. Harcourt Brace College Publishers, Florida (Chapter 2)
Hua S, Ma H, Li X, Yang H, Wang A (2010) pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium. Int J Biol Macromol 46:517–523. doi:10.1016/j.ijbiomac.2010.03.004
Reséndiz-Hernández PJ, Rodríguez-Fernández OS, García-Cerda LA (2008) Synthesis of poly(vinyl alcohol)–magnetite ferrogel obtained by freezing–thawing technique. J Magn Magn Mater 320:e373–e376. doi:10.1016/j.jmmm.2008.02.073
Guan Y, Bian J, Peng F, Zhang XM, Sun RC (2014) High strength of hemicelluloses based hydrogels by freeze/thaw technique. Carbohydr Polym 101:272–280. doi:10.1016/j.carbpol.2013.08.085
Andrade RG Jr, Dalvi LT, Silva JMC Jr, Lopes GKB, Alonso A, Hermes-Lima M (2005) The antioxidant effect of tannic acid on the in vitro copper-mediated formation of free radicals. Arch Biochem Biophys 437:1–9. doi:10.1016/j.abb.2005.02.016
Acknowledgements
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016R1A1A3A04918760).
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Hong, K.H. Polyvinyl alcohol/tannic acid hydrogel prepared by a freeze-thawing process for wound dressing applications. Polym. Bull. 74, 2861–2872 (2017). https://doi.org/10.1007/s00289-016-1868-z
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DOI: https://doi.org/10.1007/s00289-016-1868-z