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Biocompatibility studies of HDPE–HA composites with different HA content

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Abstract

High-density polyethylene–hydroxyapatite (HDPE–HA) composites with different filler content (5–20 %) were synthesized by in situ ethylene polymerization. Good filler dispersion was observed without formation of agglomerates. Osteoblast cell behavior in HDPE–HA composites was evaluated in terms of adhesion, alkaline phosphatase activity and proliferation. Fluorescence and scanning electron microscopy results showed good cell adhesion and proliferation, and extensive filopodium-like protrusion connected to hydroxyapatite particles.

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Authors and Affiliations

  1. Lab. de Polímeros, Centro de Química, Instituto Venezolano de Investigaciones Científicas (IVIC), Caracas, Venezuela

    Vanessa Hermán & Arquímedes Karam

  2. Lab. de Materiales, Centro de Ingeniería de Materiales y Nanotecnología, IVIC, Caracas, Venezuela

    Gema González & Lisbeth Lozada

  3. Lab. Bioingeniería de Tejidos-USB, Departamento Biología Celular, Universidad Simón Bolívar (USB), Caracas, Venezuela

    Karem Noris-Suárez, Laura Yndriago & Ana Marquez

  4. Escuela de Química, Facultad de Ingeniería, Universidad Central de Venezuela (UCV), Caracas, Venezuela

    Carmen Albano & Karina Romero

Authors
  1. Vanessa Hermán
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  2. Gema González
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  4. Carmen Albano
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  5. Arquímedes Karam
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Correspondence to Vanessa Hermán.

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Hermán, V., González, G., Noris-Suárez, K. et al. Biocompatibility studies of HDPE–HA composites with different HA content. Polym. Bull. 72, 3083–3095 (2015). https://doi.org/10.1007/s00289-015-1454-9

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  • DOI: https://doi.org/10.1007/s00289-015-1454-9

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