Skip to main content
SpringerLink
Log in

Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release

  • Original Paper
  • Published:
Polymer Bulletin Aims and scope Submit manuscript

Abstract

Radiation-induced copolymerization of butyl methacrylate/acrylamide has been investigated. It was observed that as the irradiation dose increases, the gelation percent increases and the maximum gelation % was achieved at irradiation dose of 30 kGy. The equilibrium swelling studies of the prepared hydrogels at various conditions were carried out in an aqueous solution. The pH sensitivity in the range of 4–7.5 was investigated. It is found that the swelling behavior of Poly(BMA/AAm) is higher than that of Poly(BMA) and Poly(AAm). Swelling kinetics and diffusion mechanism indicate that the water penetration obeys non-Fickian transport mechanism. The characterization and some selected properties of the prepared hydrogels were evaluated using FTIR, XRD, TGA and SEM. The drug release characteristics of the prepared hydrogel were studied using heparin as example of anticoagulant drug. The drug release found to be governed by multiple factors contributed by each composition of the prepared hydrogel including their drug binding affinities and water uptake rates.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Scheme 1
Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  1. He C, Zhuang X, Tang Z, Tian H, Chen X (2012) Stimuli-sensitive synthetic polypeptide-based materials for drug and gene delivery. Adv Health Mater 1:48–78

    Article  CAS  Google Scholar 

  2. He C, Kim SW, Lee DS (2008) In situ gelling stimuli-sensitive block copolymer hydrogels for drug delivery. J Controlled Release 127:189–207

    Article  CAS  Google Scholar 

  3. Danhier F, Feron O, Preat V (2010) To exploit the tumor microenvironment: passive and active tumor targeting of nano carrier for anticancer drug delivery. J Controlled Release 148:135–146

    Article  CAS  Google Scholar 

  4. Tian H, Tang Z, Zhuang X, Chen X, Jing X (2012) Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Review article. Prog Polym Sci. 37:237–280

    Article  CAS  Google Scholar 

  5. Rosiak JM, Ulanski P (1999) synthesis of hydrogels by irradiation of polymer in aqueous solution. Radiat Phys Chem 140:139–151

    Article  Google Scholar 

  6. Zhou Y, Zhao Y, Wang L, Xu L, Zhai M, Wei S (2012) Radiation synthesis and characterization of nanosilver/gelatin/carboxymethyl chitosan hydrogel. Radiat Phys Chem 81:553–560

    Article  CAS  Google Scholar 

  7. Srinivasulu B, Raghunath RP, Sundaram EV, Srinivas M, Lalitha S (1991) Reactivity ratios and thermal and dielectric studies of copolymers of acrylamide with butyl methacrylate. Eur Polym J 27:979–981

    Article  CAS  Google Scholar 

  8. Katono H, Maruyama A, Sanui K, Ogata N, Okano T, Sakurai Y (1991) Thermo-responsive swelling and drug release switching of interpenetrating polymer networks composed of poly (acrylamide-co-butyl methacrylate) and poly (acrylic acid). J Controlled Release 16:215–228

    Article  CAS  Google Scholar 

  9. Shaofeng X, Frantisek S, Fréchet JMJ (1997) Rigid porous polyacrylamide-based monolithic columns containing butyl methacrylate as a separation medium for the rapid hydrophobic interaction chromatography of proteins. J Chromatogr A 775:65–72

    Article  Google Scholar 

  10. Xiao X, Lu C (2012) Effect of mixed solvent on fabrication, morphology and monodispersity of microspheres with hydrophobic poly(butyl methacrylate) shells. J Wuhan Univ Technol Mater Sci Ed 27:048–1052

    Google Scholar 

  11. XiaoBo R, JianYong C, HuaPeng Z, HongYan T (2014) Effect of the polar molecule on copolymerization of butyl methacrylate/acrylamide. Sci China Technol Sci 44:99–107

    Google Scholar 

  12. Shem JW, Nho YC (2003) Preparation of poly (acrylic acid)/chitosan hydrogels by gamma irradiation and in vitro. J Appl Polym Sci 90:3660–3667

    Article  Google Scholar 

  13. Sokker HH, Abdel Ghaffar AM, Gad YH, Aly AS (2009) Synthesis and characterization of hydrogels based on grafted chitosan for the controlled drug release. Carbohydr Polym 75:222–229

    Article  CAS  Google Scholar 

  14. Hegazy EA, Abd El-Aal SE, AbuTalib MF, Dessouki AM (2004) Radiation synthesis and characterization of poly(N-vinyl-2-pyrrolidone/acrylic acid) and poly N-vinyl-2-pyrrolidone/acrylamide) hydrogels for some metal-ion separation. J Appl Polym Sci 92:2642–2652

    Article  CAS  Google Scholar 

  15. El-Arnaouty MB (2010) Effect of mono and di protic on the characterization of 2-hydroxyethylmethacrylate based hydrogel prepared by γ-radiation and its application for drug delivery. J Radiat Res Appl Sci 3:763–793

    Google Scholar 

  16. Hegazy EA, Ishigaki I, Okamoto J (1981) Radiation grafting of acrylic acid onto fluorine-containing polymers. I. Kinetic study of preirradiation grafting onto poly(tetrafluoroethylene). J Appl Polym Sci 26:3117–3124

    Article  CAS  Google Scholar 

  17. Hegazy EA, Dessouki AM, El-Dessouky MM, El-Sawy NM (1985) Crosslinked grafted PVC obtained by direct radiation grafting. Radiat Phys Chem 26:143–149

    Article  CAS  Google Scholar 

  18. Sokker HH, Abdel Ghaffar AM, Nada AMA (2006) Synthesis and characterization of radiation grafted copolymer for removal of nonionic organic contaminants. J Appl Polym Sci 100:3589–3595

    Article  CAS  Google Scholar 

  19. El-Hag AA, Al-Arifi A (2009) Characterization and in vitro evaluation of starch based hydrogels as carrier for colon specific drug delivery systems. Carbohydr Polym 78:725–730

    Article  Google Scholar 

  20. Bajpai AK, Giri A (2003) Water sorption behavior of highly swelling (carboxymethylcellulose-g-polyacrylamide) hydrogels and release of potassium nitrate as agrochemical. Carbohydr Polym 53:271–279

    Article  CAS  Google Scholar 

  21. Young CN, Youn ML, Young ML (2004) Preparation, properties and biological application of pH-sensitive poly(ethylene oxide) (PEO) hydrogels grafted with acrylic acid(AAc) using gamma-ray irradiation. Radiat Phys Chem 71:239–242

    Article  Google Scholar 

  22. Singh B, Chauhan GS, Sharma DK, Chauhan N (2007) The release dynamics of salicylic acid and tetracycline hydrochloride from the psyllium and polyacrylamide based hydrogels (II). Carbohydr Polym 67:559–565

    Article  CAS  Google Scholar 

  23. Vervoot L, Vanden Mooter G, Rombaut P, Augustijns P, Kinget R (1998) Inulin hydrogels. II. In vitro degradation. Int J Pharm 172:137–145

    Article  Google Scholar 

  24. Eid M, El-Arnaouty MB (2009) Kinetic degradation an controlled drug delivery system studies for sensitive hydrogels prepared by gamma irradiation. J Appl Polym Sci 112:1745

    Article  CAS  Google Scholar 

  25. Kalagasidis Krušić M, Džunuzović E, Trifunović S, Filipović J (2004) Polyacrylamide and poly (itaconic acid) complexes. Eur Polym J 40:793–798

    Article  Google Scholar 

  26. Zhang GG, Zha LS, Zhou MH, Ma JH, Liang BR (2005) Preparation and characterization of pH and temperature responsive semi-interpenetrating polymer network hydrogels based on linear sodium alginate. J Appl Polym Sci 97:1931–1940

    Article  CAS  Google Scholar 

  27. Gutowska A, Bae YH, Feijen J, Kim SW (1992) Heparin release from thermosensitive hydrogels. J Controlled Release 22:95–104

    Article  CAS  Google Scholar 

  28. Gong F, Cheng X, Wang S, Zhao Y, Gao Y, Cai H (2010) Heparin-immobilized polymer as non-inflammatory and non- thrombogenic coating materials for arsenic trioxide eluting sents. Acta Biomater 6:534–564

    Article  CAS  Google Scholar 

  29. Bastide SC, Candau S, Leibler L (1981) Osmotic deswelling of gels by polymer solution. Macromolecules. 14:719–726

    Article  CAS  Google Scholar 

  30. Simon J, Carl G, Eidelman N, Kennedy SB, Sehgal A, Khatri CA, Washburn NR (2005) Combinatorial screening of cell proliferation on poly(l-lactic acid)/poly(d, l lactic acid) blends. Biomaterials. 26:6906–6915

    Article  CAS  Google Scholar 

  31. Scotchford CA, Ball M, Winkelmann M, Voros J, Csucs C, Brunette DM, Danuser G, Textor M (2003) Chemically patterned, metal-oxide-based surfaces produced by photolithographic techniques for studying protein- and cell-interactions. II. Protein adsorption and early cell interactions. Biomaterials. 24:1147–1158

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Center for Radiation Research and Technology, Atomic Energy Authority, P.O. Box 29, Nasr City, Cairo, 11731, Egypt

    M. B. El-Arnaouty, A. M. Abdel Ghaffar, Maysara E. Aboulfotouh & N. H. Taher

  2. Department of Chemistry, Women’s College, Ain Shams University, Cairo, Egypt

    Ahmed A. Taha

Authors
  1. M. B. El-Arnaouty
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. M. Abdel Ghaffar
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maysara E. Aboulfotouh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. H. Taher
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ahmed A. Taha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. M. Abdel Ghaffar.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

El-Arnaouty, M.B., Abdel Ghaffar, A.M., Aboulfotouh, M.E. et al. Radiation synthesis and characterization of Poly(butyl methacrylate/acrylamide) copolymeric hydrogels and heparin controlled drug release. Polym. Bull. 72, 2739–2756 (2015). https://doi.org/10.1007/s00289-015-1433-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00289-015-1433-1

Keywords

Search

Navigation