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Novel immunoregulatory role of perforin-positive dendritic cells

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An Erratum to this article was published on 17 November 2016

Abstract

The recently described generation of a highly defined population of dendritic cells which express perforin and granzyme A (termed “perf-DCs”) and their ability to selectively delete cognate CD8+ T cell has raised the possibility that these cells play a role in the maintenance of peripheral tolerance. Using bone marrow transplantation, we generated mice selectively lacking perforin expressing dendritic cells. These mice progressively gain weight and exhibit features resembling metabolic syndrome as well as an enhanced susceptibility to autoimmunity induction. Interestingly, these pathological phenotypes were reversed upon treatment with CD4/CD8 neutralizing antibodies. Thus, it appears that this rare subpopulation of dendritic cells (perf-DCs) displays a major regulatory role in adipose tissue inflammatory processes and in autoimmunity.

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Authors and Affiliations

  1. Department of Immunology, Weizmann Institute of Science, Herzel St. 1, 76100, Rehovot, Israel

    Ran Orgad, Bar Nathansohn-Levi, Sivan Kagan, Yael Zlotnikov Klionsky & Yair Reisner

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  1. Ran Orgad
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  2. Bar Nathansohn-Levi
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  3. Sivan Kagan
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Correspondence to Yair Reisner.

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This article is a contribution to the special issue on Dendritic Cell Subsets and Immune-mediated Diseases - Guest Editor: Francisco Quintana

An erratum to this article is available at http://dx.doi.org/10.1007/s00281-016-0598-5.

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Orgad, R., Nathansohn-Levi, B., Kagan, S. et al. Novel immunoregulatory role of perforin-positive dendritic cells. Semin Immunopathol 39, 121–133 (2017). https://doi.org/10.1007/s00281-016-0589-6

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