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Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health

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An Erratum to this article was published on 18 August 2016

Abstract

Adaptation of the maternal immune system to establish maternal/fetal equilibrium is required for a successful pregnancy. Viral infections, including HIV-1 infection, can alter this maternal/fetal equilibrium, with significant consequences for pregnancy outcome, including miscarriages, impaired fetal growth, and premature delivery. Furthermore, maternal HIV-1 infection has been shown to have a long-term impact on the developing fetal immune system also when the infant is not infected with the virus. In this review, we discuss the consequences of maternal HIV-1 infection and antiretroviral therapy on pregnancy outcome and the health of the uninfected HIV-1-exposed infant.

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Authors and Affiliations

  1. Department of Virus Immunology, Heinrich-Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany

    Marcus Altfeld & Madeleine J. Bunders

  2. Department of Experimental Immunology, University of Amsterdam (UvA), Academic Medical Center (AMC), Amsterdam, The Netherlands

    Madeleine J. Bunders

  3. Emma Childrens Hospital,UvA, AMC, Amsterdam, The Netherlands

    Madeleine J. Bunders

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  1. Marcus Altfeld
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  2. Madeleine J. Bunders
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Correspondence to Madeleine J. Bunders.

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This article is a contribution to the special issue on Fetomaternal Cross Talk and Its Effect on Pregnancy Maintenance, Maternal and Offspring Health - Guest Editor: Petra Arck

An erratum to this article is available at http://dx.doi.org/10.1007/s00281-016-0586-9.

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Altfeld, M., Bunders, M.J. Impact of HIV-1 infection on the feto-maternal crosstalk and consequences for pregnancy outcome and infant health. Semin Immunopathol 38, 727–738 (2016). https://doi.org/10.1007/s00281-016-0578-9

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  • DOI: https://doi.org/10.1007/s00281-016-0578-9

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