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New insights into basophil heterogeneity

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Abstract

Basophils have become increasingly recognized as important innate immune cells that mediate antihelminth immunity and barrier inflammation. Recent discoveries have uncovered previously unrecognized heterogeneity in basophil populations. However, how diversity in basophil regulation and function impacts human disease remains poorly defined. The goal of the present review is to highlight how new insights into basophil heterogeneity can help us to better understand disease pathogenesis and inform the development of new therapeutics.

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Authors and Affiliations

  1. Division of Dermatology, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8123, St. Louis, MO, 63110, USA

    Landon K. Oetjen & Brian S. Kim

  2. Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, USA

    Landon K. Oetjen & Brian S. Kim

  3. Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, USA

    Landon K. Oetjen & Brian S. Kim

  4. Division of Experimental Pathology, Institute of Pathology, University of Bern, Bern, Switzerland

    Mario Noti

  5. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Brian S. Kim

  6. Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA

    Brian S. Kim

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  1. Landon K. Oetjen
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Correspondence to Brian S. Kim.

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This article is a contribution to the special issue on Basophils and Mast Cells in Immunity and Inflammation - Guest Editor: Hajime Karasuyama

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Oetjen, L.K., Noti, M. & Kim, B.S. New insights into basophil heterogeneity. Semin Immunopathol 38, 549–561 (2016). https://doi.org/10.1007/s00281-016-0567-z

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