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From proliferation to proliferation: monocyte lineage comes full circle

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Abstract

Monocytes are mononuclear circulating phagocytes that originate in the bone marrow and give rise to macrophages in peripheral tissue. For decades, our understanding of monocyte lineage was bound to a stepwise model that favored an inverse relationship between cellular proliferation and differentiation. Sophisticated molecular and surgical cell tracking tools have transformed our thinking about monocyte topo-ontogeny and function. Here, we discuss how recent studies focusing on progenitor proliferation and differentiation, monocyte mobilization and recruitment, and macrophage differentiation and proliferation are reshaping knowledge of monocyte lineage in steady state and disease.

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Authors and Affiliations

  1. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA

    Filip K. Swirski & Ingo Hilgendorf

  2. Toronto General Research Institute, Heart and Stroke Richard Lewar Centre of Excellence in Cardiovascular Research, University of Toronto, Toronto, ON, M5G1L7, Canada

    Clinton S. Robbins

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  1. Filip K. Swirski
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  2. Ingo Hilgendorf
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  3. Clinton S. Robbins
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Correspondence to Filip K. Swirski.

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This article is a contribution to the special issue on New paradigms in leukocyte trafficking, lessons for therapeutics - Guest Editors: F. W. Luscinskas and B. A. Imhof

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Swirski, F.K., Hilgendorf, I. & Robbins, C.S. From proliferation to proliferation: monocyte lineage comes full circle. Semin Immunopathol 36, 137–148 (2014). https://doi.org/10.1007/s00281-013-0409-1

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