Seminars in Immunopathology

, Volume 36, Issue 1, pp 103–114

Gut microbiome and metabolic diseases

Review

DOI: 10.1007/s00281-013-0399-z

Cite this article as:
Fukuda, S. & Ohno, H. Semin Immunopathol (2014) 36: 103. doi:10.1007/s00281-013-0399-z

Abstract

The prevalence of obesity and obesity-related disorders is increasing worldwide. In the last decade, the gut microbiota has emerged as an important factor in the development of obesity and metabolic syndrome, through its interactions with dietary, environmental, and host genetic factors. Various studies have shown that alteration of the gut microbiota, shifting it toward increased energy harvest, is associated with an obese phenotype. However, the molecular mechanisms by which the gut microbiota affects host metabolism are still obscure. In this review, we discuss the complexity of the gut microbiota and its relationship to obesity and obesity-related diseases. Furthermore, we discuss the anti-obesity potential of probiotics and prebiotics.

Keywords

Gut microbiome Metabolic syndrome Obesity Probiotics Omics 

Abbreviations

NAFLD

Non-alcoholic fatty liver disease

NASH

Non-alcoholic steatohepatitis

MGWAS

Metagenome-wide association study

TLR4

Toll-like receptor 4

LPS

Lipopolysaccharide

NOD mouse

Non-obese diabetic mouse

TMA

Trimethylamine

TMAO

Trimethylamine N-oxide

FMOs

Flavin monooxygenases

CLA

Conjugated linoleic acid

GLP-1

Glucagon like peptide-1

SCFA

Short-chain fatty acid

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Institute for Advanced BiosciencesKeio UniversityTsuruokaJapan
  2. 2.Laboratory for Intestinal EcosystemRIKEN Center for Integrative Medical Sciences (IMS-RCAI)YokohamaJapan

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