Original Paper

Springer Seminars in Immunopathology

, Volume 26, Issue 3, pp 289-307

Dendritic cell-mediated T cell polarization

  • Esther C. de JongAffiliated withDepartment of Cell Biology and Histology, Academic Medical Center, University of Amsterdam Email author 
  • , Hermelijn H. SmitsAffiliated withDepartment of Cell Biology and Histology, Academic Medical Center, University of AmsterdamDepartment of Parasitology, Leiden University Medical Center
  • , Martien L. KapsenbergAffiliated withDepartment of Cell Biology and Histology, Academic Medical Center, University of AmsterdamDepartment of Dermatology, Academic Medical Center, University of Amsterdam

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Abstract

Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4+ T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.

Keywords

Th1 cells Th2 cells Regulatory T cells Cytokines Costimulatory molecules