Springer Seminars in Immunopathology

, Volume 26, Issue 3, pp 289–307

Dendritic cell-mediated T cell polarization

Authors

    • Department of Cell Biology and Histology, Academic Medical CenterUniversity of Amsterdam
  • Hermelijn H. Smits
    • Department of Cell Biology and Histology, Academic Medical CenterUniversity of Amsterdam
    • Department of ParasitologyLeiden University Medical Center
  • Martien L. Kapsenberg
    • Department of Cell Biology and Histology, Academic Medical CenterUniversity of Amsterdam
    • Department of Dermatology, Academic Medical CenterUniversity of Amsterdam
Original Paper

DOI: 10.1007/s00281-004-0167-1

Cite this article as:
de Jong, E.C., Smits, H.H. & Kapsenberg, M.L. Springer Semin Immun (2005) 26: 289. doi:10.1007/s00281-004-0167-1

Abstract

Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4+ T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.

Keywords

Th1 cellsTh2 cellsRegulatory T cellsCytokinesCostimulatory molecules

Copyright information

© Springer-Verlag 2004