Skip to main content

Advertisement

Log in

Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13;17)(q12;q25) after prior breast cancer and acute promyelocytic leukemia

  • Letter to the Editor
  • Published:
Annals of Hematology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Latagliata R, Petti MC, Fenu S, Mancini M, Spiriti MA, Breccia M, Brunetti GA, Avvisati G, Lo Coco F, Mandelli F (2002) Therapy-related myelodysplastic syndrome—acute myelogenous leukemia in patients treated for acute promyelocytic leukemia: an emerging problem. Blood 99(3):822–824

    Article  CAS  PubMed  Google Scholar 

  2. Leone G, Voso MT, Sica S, Morosetti R, Pagano L (2001) Therapy related leukemias: susceptibility, prevention and treatment. Leuk Lymphoma 41(3–4):255–276. doi:10.3109/10428190109057981

    Article  CAS  PubMed  Google Scholar 

  3. Lobe I, Rigal-Huguet F, Vekhoff A, Desablens B, Bordessoule D, Mounier C, Ferrant A, Sanz M, Fey M, Chomienne C, Chevret S, Degos L, Fenaux P, European APLge (2003) Myelodysplastic syndrome after acute promyelocytic leukemia: the European APL group experience. Leukemia 17(8):1600–1604. doi:10.1038/sj.leu.2403034

    Article  CAS  PubMed  Google Scholar 

  4. Montesinos P, Gonzalez JD, Gonzalez J, Rayon C, de Lisa E, Amigo ML, Ossenkoppele GJ, Penarrubia MJ, Perez-Encinas M, Bergua J, Deben G, Sayas MJ, de la Serna J, Ribera JM, Bueno J, Milone G, Rivas C, Brunet S, Lowenberg B, Sanz M (2010) Therapy-related myeloid neoplasms in patients with acute promyelocytic leukemia treated with all-trans-retinoic acid and anthracycline-based chemotherapy. J of Clin Oncol Off J Am Soc Clin Oncolo 28(24):3872–3879. doi:10.1200/JCO.2010.29.2268

    Article  CAS  Google Scholar 

  5. Bally C, Thepot S, Quesnel B, Vey N, Dreyfus F, Fadlallah J, Turlure P, de Botton S, Dartigeas C, de Renzis B, Itzykson R, Fenaux P, Ades L (2013) Azacitidine in the treatment of therapy related myelodysplastic syndrome and acute myeloid leukemia (tMDS/AML): a report on 54 patients by the Groupe Francophone Des Myelodysplasies (GFM). Leuk Res 37(6):637–640. doi:10.1016/j.leukres.2013.02.014

    Article  CAS  PubMed  Google Scholar 

  6. Turturro F, Leary C, Stephens J, Veillon D, Lowery-Nordberg M (2010) Caution using hypomethylating agents in myelodysplasia or myeloid leukemia with complex cytogenetics. J Clin Oncol Off J Am Soc Clin Oncol 28(22):e380–381. doi:10.1200/JCO.2010.28.5775

    Article  Google Scholar 

  7. Scaglioni PP, Cai LF, Majid SM, Yung TM, Socci ND, Kogan SC, Kopelovich L, Pandolfi PP (2011) Treatment with 5-azacytidine accelerates acute promyelocytic leukemia leukemogenesis in a transgenic mouse model. Genes & cancer 2(2):160–165. doi:10.1177/1947601911410300

    Article  CAS  Google Scholar 

  8. Pleyer L, Burgstaller S, Girschikofsky M, Linkesch W, Stauder R, Pfeilstocker M, Schreder M, Tinchon C, Sliwa T, Lang A, Sperr WR, Krippl P, Geissler D, Voskova D, Schlick K, Thaler J, Machherndl-Spandl S, Theiler G, Eckmullner O, Greil R (2014) Azacitidine in 302 patients with WHO-defined acute myeloid leukemia: results from the Austrian Azacitidine Registry of the AGMT-Study Group. Ann Hematol 93(11):1825–1838. doi:10.1007/s00277-014-2126-9

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Yi JH, Huh J, Kim HJ, Kim SH, Kim SH, Kim KH, Do YR, Mun YC, Kim H, Kim MK, Kim HJ, Kim T, Kim DD (2013) Genome-wide single-nucleotide polymorphism array-based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment. Ann Hematol 92(4):459–469. doi:10.1007/s00277-012-1635-7

    Article  CAS  PubMed  Google Scholar 

  10. Abaigar M, Ramos F, Benito R, Diez-Campelo M, Sanchez-del-Real J, Hermosin L, Rodriguez JN, Aguilar C, Recio I, Alonso JM, de las Heras N, Megido M, Fuertes M, del Canizo MC, Hernandez-Rivas JM (2013) Prognostic impact of the number of methylated genes in myelodysplastic syndromes and acute myeloid leukemias treated with azacytidine. Ann Hematol 92(11):1543. doi:10.1007/s00277-013-1799-9

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

O.J. and V.P. have received a speaker honorarium from Celgene. Other authors declare that they have no conflict of interest.

Informed consent

Patient gave written informed consent for all procedures and for publishing.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ozren Jaksic.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lucijanic, M., Lasan-Trcic, R., Kusec, R. et al. Loss of response to azacitidine is associated with deletion 12p13 in a patient with myelodysplastic syndrome with unique translocation t(13;17)(q12;q25) after prior breast cancer and acute promyelocytic leukemia. Ann Hematol 94, 1617–1619 (2015). https://doi.org/10.1007/s00277-015-2428-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00277-015-2428-6

Keywords

Navigation