Abstract
Monosomal karyotype (MK) in acute myeloid leukemia (AML) is associated with an extremely poor outcome. The clinical significance of MK and the role of allogeneic hematopoietic cell transplantation (HCT) were evaluated in 749 Korean patients with newly diagnosed AML. MK was found in 9.3 % of patients and was more frequent in patients with advanced age or secondary AML. Patients with MK had significantly lower blood leukocyte counts and bone marrow blast percentages, and they had lower complete remission (CR) rate (43 %) and shorter median overall survival (OS) (6.5 months) and relapse-free survival (RFS) (10.0 months) than any other prognostic group. MK+ patients who received allogeneic HCT at the first CR had higher OS [hazard ratio (HR) 0.344, P = 0.018], RFS (HR 0.257, P = 0.006), and lower relapse probability (HR 0.264, P = 0.008) than those not receiving. This study’s results confirmed poor outcomes for AML patients with MK and suggest that allogeneic HCT at the first CR may improve outcome.
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Acknowledgments
Yunsuk Choi analyzed the data and wrote the manuscript; Je-Hwan Lee designed the study, analyzed the data, and contributed to the writing of the manuscript; Eul-Ju Seo, Chan-Jung Park, Seongsoo Jang, Young-Uk Cho analyzed data; Jung-Hee Lee, Dae-Young Kim, Miee Seol, Young-Shin Lee, Young-A Kang, Mijin Jeon and Kyoo-Hyung Lee collected the clinical data. All authors participated in the critical revision of the manuscript, and each gave final approval for the submission of this manuscript. This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea. HI06C0868 (A062254)
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Choi, Y., Lee, JH., Seo, EJ. et al. Monosomal karyotype in acute myeloid leukemia and the role of allogeneic hematopoietic cell transplantation. Ann Hematol 94, 795–801 (2015). https://doi.org/10.1007/s00277-014-2286-7
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DOI: https://doi.org/10.1007/s00277-014-2286-7