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The Glasgow Prognostic Score as a significant predictor of diffuse large B cell lymphoma treated with R-CHOP in China

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Abstract

The Glasgow Prognostic Score (GPS) incorporates C-reactive protein and albumin as clinically useful markers of tumor behavior and shows significant prognostic value in several types of solid tumors. The accuracy of the GPS in predicting outcomes in diffuse large B cell lymphoma (DLBCL) remains unknown. We performed this study to evaluate the prognostic significance of the GPS in DLBCL in China. We retrospectively analyzed 160 patients with newly diagnosed DLBCL at the Shanghai Ruijin Hospital (China). The prognostic value of the GPS was evaluated and compared with that of the International Prognostic Index (IPI) and immunohistochemical subtyping. The GPS was defined as follows: GPS-0, C-reactive protein (CRP) ≤10 mg/L and albumin ≥35 g/L; GPS-1, CRP >10 mg/L or albumin <35 g/L; and GPS-2, CRP >10 mg/L and albumin <35 g/L. Patients with lower GPS tended to have better outcomes including progression-free survival (PFS, P < 0.001) and overall survival (OS, P < 0.001). Multivariate analysis demonstrated that high GPS and high IPI score were independent adverse predictors of OS. Similar to several other tumors, GPS is a reliable predictor of survival outcomes in DLBCL patients treated with R-CHOP therapy. Inflammatory responses are implicated in the progression and survival of patients with DLBCL.

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Acknowledgments

This work is supported by the Program for Outstanding Young Teachers in Universities of Shanghai, and the Natural Science Foundation of Shanghai (14ZR1425900). We would like to express appreciation to the research assistants for their diligence and attentiveness to detail and the outstanding clinical care delivered by all staffs.

Conflict of interest

The authors declare no competing financial interests.

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Correspondence to Junmin Li.

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Xiaoyang Li and Yunxiang Zhang contributed equally to this work.

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Li, X., Zhang, Y., Zhao, W. et al. The Glasgow Prognostic Score as a significant predictor of diffuse large B cell lymphoma treated with R-CHOP in China. Ann Hematol 94, 57–63 (2015). https://doi.org/10.1007/s00277-014-2167-0

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  • DOI: https://doi.org/10.1007/s00277-014-2167-0

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