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Long-term survival of patients with a history of venous thromboembolism

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Abstract

Limited data are available regarding long-term survival following venous thromboembolism (VTE). The objectives of this study are to evaluate long-term survival by retrospective survival analysis in patients with a history of VTE and to compare their survival with that of the general population. Patients with a history of VTE (min. 3 months after VTE) without cancer, who were referred to our department between 1994 and 2007, were included in the analysis. Information concerning mortality was available through the Austrian Central Death Register. The survival of patients was compared with that of the age- and gender-matched general Austrian population. Three thousand two hundred-nine patients (mean age, 46.2; range, 14–89 years) were included. Median time interval between the first VTE and inclusion was 14 months; median observation period was 6.6 years. During the considered time period, 169 patients (5.3%) died. The cumulative survival in patients was 0.97 and 0.87 after 5 and 10 years; men had a higher death rate than women; patients with idiopathic VTE had a less favourable survival than those with a triggering event. When patients were compared to the general population, the cumulative relative survival was 1.02 (95% CI 1.00–1.03). In none of the analysed subgroups (different sites of VTE; idiopathic vs. secondary VTE) was a reduced cumulative relative survival found. The relative survival of male patients was even slightly better, whereas that of women equalled that of the normal population. Our results indicate that after the initial phase, VTE does not seem to impair long-term survival of patients with a history of VTE without cancer.

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Acknowledgements

We thank Tanja Altreiter, MA (Clinical Division of Haematology and Haemostaseology, Department of Medicine I, Medical University Vienna) for proofreading of the manuscript.

Disclosure of conflicts of interests

The authors state that they have no conflicts of interest.

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Authors and Affiliations

  1. Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria

    Sylvia Elisabeth Reitter, Michaela Mayerhofer, Cihan Ay, Paul Alexander Kyrle & Ingrid Pabinger

  2. Center for Public Health, Department of Epidemiology, Medical University Vienna, Vienna, Austria

    Thomas Waldhoer

  3. Section of Medical Information Management und Imaging, Center for Medical Statistics, Infomatics and Intelligent Systems, Medical University Vienna, Vienna, Austria

    Ernst Eigenbauer

Authors
  1. Sylvia Elisabeth Reitter
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  2. Thomas Waldhoer
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  3. Michaela Mayerhofer
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  4. Ernst Eigenbauer
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  5. Cihan Ay
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  6. Paul Alexander Kyrle
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  7. Ingrid Pabinger
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Corresponding author

Correspondence to Ingrid Pabinger.

Additional information

Dr. Reitter is recipient of a Bayer Haemophilia Clinical Training Award.

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Reitter, S.E., Waldhoer, T., Mayerhofer, M. et al. Long-term survival of patients with a history of venous thromboembolism. Ann Hematol 90, 585–594 (2011). https://doi.org/10.1007/s00277-011-1160-0

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  • DOI: https://doi.org/10.1007/s00277-011-1160-0

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