Severe infectious complications in a patient treated with rituximab for idiopathic thrombocytopenic purpura
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Rituximab has been recently employed in the treatment of patients with refractory chronic idiopathic thrombocytopenic purpura (ITP). Rarely, infectious complications due to rituximab treatment in chronic ITP are registered [1, 2].
In a 39-year-old immunocompetent man, after treatment with Clopidogrel for an acute coronary syndrome, diagnosis of ITP [platelet count (Plt) 59 × 109/l] was established on April 2003. He did not receive any treatment for more than 1 year due to Plt > 30 × 109/l. In January 2005, he presented a progressive reduction of Plt until 13 × 109/l and gingival bleeding; he started treatment with high-dose dexamethasone 40 mg p.o. pulsed for 4 days every 2 weeks , obtaining after three courses a partial response (Plt between 30 and 50 × 109).
In June 2005, Plt dropped to 23 × 109/l. Low doses of prednisone p.o. (10 mg every other day) was started, achieving a Plt > 30 × 109/l. On November 2005, because of unstable Plt, the patient was candidate to a secon ...
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- Severe infectious complications in a patient treated with rituximab for idiopathic thrombocytopenic purpura
Annals of Hematology
Volume 86, Issue 3 , pp 225-226
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- 1. Istituto di Ematologia, Università Cattolica del Sacro Cuore, Largo A. Gemelli, 8-00168, Rome, Italy
- 2. Istituto di Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy