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Clonal relationship in multifocal non-Hodgkin’s lymphoma of mucosa-associated lymphoid tissue (MALT)

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Abstract

To elucidate the progression of gastric marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type, we analyzed a case presenting simultaneously with MALT lymphoma of the stomach and lung, and a gastric high-grade diffuse large lymphoma. The rearranged immunoglobulin heavy chain (IgH) variable regions were analyzed using a polymerase chain reaction (PCR)-based assay. Clonal relationship was shown between the gastric high-grade and the pulmonary low-grade lymphoma. The gastric MALT lymphoma was not related to the other manifestations. Translocation t(11;18) was not detected in the gastric high-grade lymphoma. MALT lymphomas at various locations and with different histologies may derive from a common precursor cell. Lymphomas at identical sites may have different stem cells.

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Author notes

  1. B. Alpen

    Present address: Department for Radiooncology, Charité Hospital of Humboldt University, Berlin, Germany

Authors and Affiliations

  1. Department for Internal Medicine, Hematology, Oncology, Immunology, Hospital of the Philipps University, Baldingerstraße, 35043, Marburg, Germany

    B. Alpen, T. Wündisch & A. Neubauer

  2. Department for Oncology and Hematology, University-Hospital Eppendorf, Hamburg, Germany

    J. Dierlamm

  3. Elisabeth Hospital, Essen, Germany

    G. Börsch

  4. Institute for Pathology, Hospital Bayreuth, Bayreuth, Germany

    M. Stolte

Authors
  1. B. Alpen
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  2. T. Wündisch
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  3. J. Dierlamm
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  4. G. Börsch
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  5. M. Stolte
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  6. A. Neubauer
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Corresponding author

Correspondence to A. Neubauer.

Additional information

Supported in part by Deutsche Krebshilfe (70–2251-Ne1) and the Kempkes Stiftung

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Alpen, B., Wündisch, T., Dierlamm, J. et al. Clonal relationship in multifocal non-Hodgkin’s lymphoma of mucosa-associated lymphoid tissue (MALT). Ann Hematol 83, 124–126 (2004). https://doi.org/10.1007/s00277-003-0763-5

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  • DOI: https://doi.org/10.1007/s00277-003-0763-5

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