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Comparison of Pain Within 24 h after Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres Versus Gelatin Sponge Particles for Leiomyoma

  • Clinical Investigation
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Abstract

Purpose

To compare acute pain after uterine artery embolization (UAE) with tris-acryl gelatin microspheres (TAGM) versus gelatin sponge particles (GS) for leiomyoma.

Materials and Methods

This was a single-institution, retrospective study. Between July 2008 and November 2016, 101 consecutive patients with symptomatic uterine leiomyoma underwent UAE with the same protocol for post-procedural pain. GS was employed with near-stasis endpoint for the first 49 patients, whereas TAGM was used with limited endpoint for the next 52 patients. Post-UAE pain levels were compared between both groups with a linear mixed model using visual analog scale (VAS) scores from 0 to 18 h as a repeat measure outcome. Peak VAS < 24 h or dose of drugs for analgesia and conscious sedation was compared by analysis of variance. Tumor infarction was assessed with post-procedural contrast-enhanced MRI.

Results

Baseline demographics and most outcomes including tumor infarction were similar between both groups. The average VAS scores during the period <24 h were significantly lower in TAGM group (1.68, 95% CI 1.23–2.13) compared to GS group (3.28, 95% CI 2.82–3.74, p < 0.0001). The difference remained significant even after adjustment for other factors (p < 0.0001). The mean peak VAS < 24 h was also lower in TAGM group (3.89, 95% CI 3.25–4.53) than in GS group (5.90, 95% CI 5.20–6.53, p < 0.0001). The dose of drugs for analgesia and conscious sedation was significantly lower in TAGM group (p = 0.001, p = 0.004, respectively).

Conclusion

TAGM had an advantage over GS in UAE for leiomyoma in terms of less post-procedural pain <24 h, with lower doses of drugs for analgesia and conscious sedation.

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Authors and Affiliations

  1. Department of Radiology, Saiseikai Shiga Hospital, Ohashi 2-4-1, Ritto, Shiga, 520-3046, Japan

    Tetsuya Katsumori & Shunsuke Asai

  2. Department of Preventive Medicine and Public Health Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan

    Hisatomi Arima

  3. Department of Radiology, Osaka General Hospital of West Japan Railway Company, 1-2-22 Matsuzaki-cho, Abeno, Osaka, 545-0053, Japan

    Natsuko Hayashi

  4. Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kyoto, 602-8566, Japan

    Hiroshi Miura

Authors
  1. Tetsuya Katsumori
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  2. Hisatomi Arima
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Correspondence to Tetsuya Katsumori.

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Conflict of interest

Tetsuya Katsumori has received payment for lectures and writing articles from Nippon Kayaku. The payments are not related to the present manuscript. The other authors have no conflict of interest.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Katsumori, T., Arima, H., Asai, S. et al. Comparison of Pain Within 24 h after Uterine Artery Embolization with Tris-Acryl Gelatin Microspheres Versus Gelatin Sponge Particles for Leiomyoma. Cardiovasc Intervent Radiol 40, 1687–1693 (2017). https://doi.org/10.1007/s00270-017-1691-4

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  • DOI: https://doi.org/10.1007/s00270-017-1691-4

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