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Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases

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Abstract

Objectives

This study aimed to evaluate the progress of future liver remnant volume (FLRV) in patients with liver metastases after portal vein embolization (PVE) with the application of hematopoietic stem cells (HSCs) and compare it with a patients control group after PVE only.

Methods

Twenty patients (group 1) underwent PVE with contralateral HSC application. Subsequently, CT volumetry with the determination of FLRV was performed at weekly intervals, in total three weeks. A sample of twenty patients (group 2) who underwent PVE without HSC application was used as a control group.

Results

The mean of FLRV increased by 173.2 mL during three weeks after the PVE/HSC procedure, whereas by 98.9 mL after PVE only (p = 0.015). Furthermore, the mean daily growth of FLRV by 7.6 mL in group 1 was significantly higher in comparison with 4.1 mL in group 2 (p = 0.007).

Conclusions

PVE with the application of HSC significantly facilitates growth of FLRV in comparison with PVE only. This method could be one of the new suitable approaches to increase the resectability of liver tumours.

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Acknowledgements

This research was supported by the Charles University Research Fund (Project Number P36) and by the Ministry of Health, Czech Republic—the project of conceptual development of research organization (Faculty Hospital in Pilsen—FNPl, 00669806).

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Authors and Affiliations

  1. Department of Imaging Methods, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic

    Jaroslav Ludvík, Petr Duras, Táňa Matoušková, Jiří Ferda & Jan Baxa

  2. Department of Surgery, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic

    Vladislav Třeška, Jan Brůha & Jakub Fichtl

  3. Department of Haemato-Oncology, University Hospital and Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic

    Daniel Lysák

  4. alej Svobody 80, 30460, Plzeň, Czech Republic

    Jaroslav Ludvík

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  1. Jaroslav Ludvík
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  2. Petr Duras
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Correspondence to Jaroslav Ludvík.

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Ludvík, J., Duras, P., Třeška, V. et al. Portal Vein Embolization with Contralateral Application of Stem Cells Facilitates Increase of Future Liver Remnant Volume in Patients with Liver Metastases. Cardiovasc Intervent Radiol 40, 690–696 (2017). https://doi.org/10.1007/s00270-017-1566-8

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  • DOI: https://doi.org/10.1007/s00270-017-1566-8

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