Abstract
Purpose
The purpose of this work was to evaluate blood pressure changes caused by deployment of the Surefire antireflux expandable tip. The pressure measurements are relevant because they imply changes in hepatoenteric arterial blood flow within this liver compartment during hepatic artery delivery of cytotoxic agents.
Methods
After positioning the Surefire antireflux system in the targeted hepatic artery, blood pressure was obtained initially with the tip collapsed (or through a femoral artery sheath), then again after the tip was expanded before chemoembolization or yttrium 90 (90Y) radioembolization.
Results
Eighteen patients with liver malignancy underwent 29 procedures in 29 hepatic arteries (3 common hepatic, 22 lobar, 4 segmental). Systolic, diastolic, and mean blood pressure were all decreased by a mean of 29 mm Hg (p = 0.000004), 14 mm Hg (p = 0.0000004), and 22 mm Hg (p = 0.00000001), respectively.
Conclusion
When the Surefire expandable tip is deployed to prevent retrograde reflux of agents, it also results in a significant decrease in blood pressure in the antegrade distribution, potentially resulting in hepatopedal blood flow in vessels that are difficult to embolize, such as the supraduodenal arteries.
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Acknowledgments
We express gratitude to Azniv Zeronian for assistance in preparation of this manuscript and to Lori-Ann Santamaria, Surefire Medical for assistance with statistical analysis.
Conflict of interest
S. C. Rose has a potential conflicts of interest in having been a speaker for this company and potentially developing a patent for the SIS device. J. Chomas is a stockholder and CEO of Surefire Medical.
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Rose, S.C., Kikolski, S.G. & Chomas, J.E. Downstream Hepatic Arterial Blood Pressure Changes Caused by Deployment of the Surefire AntiReflux Expandable Tip. Cardiovasc Intervent Radiol 36, 1262–1269 (2013). https://doi.org/10.1007/s00270-012-0538-2
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DOI: https://doi.org/10.1007/s00270-012-0538-2