Abstract
Purpose
To evaluate the incidence and cause of hypertension prospectively during adrenal radiofrequency ablation (RFA).
Methods
For this study, approved by our institutional review board, written informed consent was obtained from all patients. Patients who received RFA for adrenal tumors (adrenal ablation) and other abdominal tumors (nonadrenal ablation) were included in this prospective study. Blood pressure was monitored during RFA. Serum adrenal hormone levels including epinephrine, norepinephrine, dopamine, and cortisol levels were measured before and during RFA. The respective incidences of procedural hypertension (systolic blood pressure >200 mmHg) of the two patient groups were compared. Factors correlating with procedural systolic blood pressure were evaluated by regression analysis.
Results
Nine patients underwent adrenal RFA and another 9 patients liver (n = 5) and renal (n = 4) RFA. Asymptomatic procedural hypertension that returned to the baseline by injecting calcium blocker was found in 7 (38.9%) of 18 patients. The incidence of procedural hypertension was significantly higher in the adrenal ablation group (66.7%, 6/9) than in the nonadrenal ablation group (11.1%, 1/9, P < 0.0498). Procedural systolic blood pressure was significantly correlated with serum epinephrine (R 2 = 0.68, P < 0.0001) and norepinephrine (R 2 = 0.72, P < 0.0001) levels during RFA. The other adrenal hormones did not show correlation with procedural systolic blood pressure.
Conclusion
Hypertension occurs frequently during adrenal RFA because of the release of catecholamine.
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Yamakado, K., Takaki, H., Yamada, T. et al. Incidence and Cause of Hypertension During Adrenal Radiofrequency Ablation. Cardiovasc Intervent Radiol 35, 1422–1427 (2012). https://doi.org/10.1007/s00270-012-0348-6
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DOI: https://doi.org/10.1007/s00270-012-0348-6