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Glasgow Prognostic Score and Prognosis After Hepatectomy for Hepatocellular Carcinoma

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An Erratum to this article was published on 08 March 2017

Abstract

Background

Systemic inflammation can promote tumor growth. The Glasgow Prognostic Score (GPS), a simple assessment of systemic inflammation status, could be useful to predict the prognosis of hepatocellular carcinoma (HCC) patients after hepatectomy.

Methods

Consecutive HCC patients were enrolled following hepatectomy at our institution between 2005 and 2012. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival. Patients were stratified according to the GPS. To minimize selection bias, propensity score analysis was performed.

Results

An elevated GPS (1–2), des-gamma carboxyprothrombin levels (≥40 mAU/mL), and the presence of multiple tumors were significantly associated with a poor OS. Alpha-fetoprotein levels (≥20.0 ng/mL), des-gamma carboxyprothrombin levels (≥40 mAU/mL), and the presence of multiple tumors were independent risk factors for a poor recurrence-free survival. After one-to-one matching, 92 patients each with a normal GPS (0) and an elevated GPS (1–2) had similar preoperative and operative characteristics. Poorer OS times in patients with an elevated GPS were confirmed by excluding possible misinterpretation.

Conclusions

An elevated GPS was an independent prognostic indicator for OS after hepatectomy in HCC patients. The GPS, which employs inexpensive and readily available biomarkers, could be a novel tool for predicting survival in such patients.

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Acknowledgements

We wish to thank the Center of Life Science, Hiroshima University (Hiroshima, Japan) for the use of their facilities.

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Authors and Affiliations

  1. Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    Tomoyuki Abe, Tsuyoshi Kobayashi, Shintaro Kuroda & Hideki Ohdan

  2. Department of Surgery, Kure Medical Center, National Hospital Organization, 3-1 Aoyama, Kure, Hiroshima, 737-0023, Japan

    Hirotaka Tashiro

  3. Advanced Medical Skills Training Center, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan

    Minoru Hattori

Authors
  1. Tomoyuki Abe
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  2. Hirotaka Tashiro
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  3. Tsuyoshi Kobayashi
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  4. Minoru Hattori
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  5. Shintaro Kuroda
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  6. Hideki Ohdan
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Corresponding author

Correspondence to Hirotaka Tashiro.

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The authors declare that they have no actual or potential conflicts of interests.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00268-017-3914-x.

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Abe, T., Tashiro, H., Kobayashi, T. et al. Glasgow Prognostic Score and Prognosis After Hepatectomy for Hepatocellular Carcinoma. World J Surg 41, 1860–1870 (2017). https://doi.org/10.1007/s00268-017-3909-7

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