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Identification of Risk Factors for Pancreatic Exocrine Insufficiency After Pancreaticoduodenectomy Using a 13C-Labeled Mixed Triglyceride Breath Test

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Abstract

Background

There are only a few reports concerning long-term exocrine function after pancreaticoduodenectomy (PD), although the number of long-term survivors has increased. We assessed pancreatic exocrine function after PD in 189 patients to identify risk factors for pancreatic exocrine insufficiency.

Methods

We evaluated patients’ exocrine function by using the 13C-labeled mixed triglyceride breath test, a noninvasive test feasible in outpatient service units. The present study included 99 patients that underwent pancreaticojejunostomy (PJ) at Wakayama Medical University Hospital and 90 patients that underwent pancreaticogastrostomy (PG) at Hiroshima University Hospital, the standard reconstruction techniques during PD at the respective hospitals. We also analyzed long-term morphological changes of remnant pancreas by computed tomography (main pancreatic duct dilation and parenchymal atrophy), nutritional status, and endocrine function.

Results

Independent risk factors for exocrine insufficiency after PD include hard pancreas (P = 0.003, odds ratio; 3.157) and PG reconstruction (P = 0.040, odds ratio; 2.321). Breath test results correlated significantly with post-operative morphological changes, nutritional status, and endocrine function. Atrophic changes of the remnant pancreas in the PG group were more severe than those in the PJ group. Furthermore, for patients with a soft pancreas, postoperative body weight changes, prognostic nutritional index, serum total protein levels as well as exocrine test were worse in the PG group, compared with the PJ group.

Conclusions

Our results showed that PJ reconstruction might be superior to PG during PD, from the viewpoint of long-term pancreatic exocrine function, although further prospective studies are needed.

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Authors and Affiliations

  1. Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama, 641-8510, Japan

    Seiko Hirono, Masaji Tani, Manabu Kawai, Ken-ichi Okada & Hiroki Yamaue

  2. Department of Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

    Yoshiaki Murakami, Kenichiro Uemura, Takeshi Sudo, Yasushi Hashimoto, Naoya Nakagawa & Naru Kondo

Authors
  1. Seiko Hirono
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  2. Yoshiaki Murakami
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  3. Masaji Tani
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  4. Manabu Kawai
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  5. Ken-ichi Okada
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  6. Kenichiro Uemura
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  7. Takeshi Sudo
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  8. Yasushi Hashimoto
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  9. Naoya Nakagawa
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  10. Naru Kondo
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  11. Hiroki Yamaue
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Correspondence to Yoshiaki Murakami.

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Hirono, S., Murakami, Y., Tani, M. et al. Identification of Risk Factors for Pancreatic Exocrine Insufficiency After Pancreaticoduodenectomy Using a 13C-Labeled Mixed Triglyceride Breath Test. World J Surg 39, 516–525 (2015). https://doi.org/10.1007/s00268-014-2832-4

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  • DOI: https://doi.org/10.1007/s00268-014-2832-4

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