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Current Strategies for Surgical Management and Adjuvant Treatment of Childhood Papillary Thyroid Carcinoma

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Abstract

Childhood papillary thyroid carcinoma is associated with more locally aggressive and more frequent distant disease than its adult counterpart. Recurrence rates tend to be higher in children, but cause-specific mortality remains low. Optimal initial treatment of childhood papillary thyroid carcinoma should include total or near-total thyroidectomy and central compartment node clearance. Modified neck dissections should be performed for biopsy-proven lateral neck disease. Every effort should be made to maintain parathyroid and laryngeal nerve function. Radical neck dissections are to be avoided. Radioiodine remnant ablation (RRA), appropriate thyroid hormone suppressive therapy (THST), and judicious use of therapeutic doses of 131I are applied to achieve a disease-free status, which is most often confirmed by negative neck ultrasonography, negative whole-body scan (either withdrawal or recombinant human thyroid-stimulating hormone-stimulated), and extremely low levels of serum thyroglobulin. Appropriate utilization of 131I, THST, repeat surgery, external beam radiotherapy, and rarely chemotherapy may provide long-term palliation and some cures in patients with recurrent/persistent disease. Follow-up should be lifelong, and the care of children after age 17 should subsequently be transferred to adult-care endocrinologists with expertise in managing thyroid neoplasia. Optimal surgical management can be achieved if adequate operations are routinely carried out by “high-volume” thyroid surgeons with expertise in the care of children. Nowhere is a multidisciplinary approach (endocrinologists, surgeons, nuclear medicine physicians, pediatricians, pathologists, oncologists) more critical than in the long-term management of papillary thyroid carcinoma that presents during childhood.

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References

  1. W Hung NJ Sarlis (2002) ArticleTitleCurrent controversies in the management of pediatric patients with well-differentiated nonmedullary thyroid cancer: a review Thyroid 12 683–702 Occurrence Handle10.1089/105072502760258668 Occurrence Handle12225637

    Article  PubMed  Google Scholar 

  2. Bernstein L, Gurney JG. Carcinomas and Other Malignant Epithelial Neoplasms. ICCC XI. Pediatric Monograph, NCI Seer. Available at www.seer.cancer.gov/Publications/childhood/carcinomas.pdf

  3. Harness JK. Childhood thyroid carcinoma. In Clark OH, Duh Q-Y, editors, Textbook of Endocrine Surgery, Philadelphia, Saunders, 1997;75–81

  4. JL Young CL Percy AJ Asire et al. (1981) ArticleTitleCancer incidence and mortality in the United States, 1973-1977 Natl. Cancer Inst. Monogr. 57 1

    Google Scholar 

  5. HR Harach ED Williams (1995) ArticleTitleChildhood thyroid cancer in England and Wales Br. J. Cancer 72 777–783 Occurrence Handle7669594

    PubMed  Google Scholar 

  6. InstitutionalAuthorNameLiVolsi VA (1992) ArticleTitlePapillary neoplasms of the thyroid: pathologic and prognostic features Am. J. Clin. Pathol. 97 426

    Google Scholar 

  7. SS Stoffer DL Dyke ParticleVan J VandenBach et al. (1986) ArticleTitleFamilial papillary carcinoma of the thyroid Am. J. Med. Genet. 25 775 Occurrence Handle1:STN:280:BiiD2szltl0%3D Occurrence Handle3789026

    CAS  PubMed  Google Scholar 

  8. BJ Duffy PJ Fitzgerald (1950) ArticleTitleCancer of the thyroid in children: a report of 28 cases J. Clin. Endocrinol. Metab. 10 1296 Occurrence Handle14794754

    PubMed  Google Scholar 

  9. T Winship R Rosvoll (1970) ArticleTitleThyroid carcinoma in children: final report of a 20-year study Clin. Proc. Child. Hosp. D.C. 26 11

    Google Scholar 

  10. JK Harness NW Thompson MK McLeod et al. (1992) ArticleTitleDifferentiated thyroid carcinoma in children and adolescents World J. Surg. 16 547–554 Occurrence Handle1:STN:280:ByyD3szltVE%3D Occurrence Handle1413825

    CAS  PubMed  Google Scholar 

  11. C Ceccarelli F Pacini F Lippi et al. (1988) ArticleTitleThyroid cancer in children and adolescents Surgery 104 1143–1148 Occurrence Handle1:STN:280:BiaD2MfotFE%3D Occurrence Handle3194841

    CAS  PubMed  Google Scholar 

  12. H Goepfert WJ Dichtel NA Samaan (1984) ArticleTitleThyroid cancer in children and teenagers Arch. Otolaryngol. 110 72 Occurrence Handle1:STN:280:BiuC38jlt1I%3D Occurrence Handle6696687

    CAS  PubMed  Google Scholar 

  13. JA Buckwalter NJ Gurll CG Thomas SuffixJr (1981) ArticleTitleCancer of the thyroid in youth World J. Surg. 5 15 Occurrence Handle1:STN:280:Bi6B3c3mtFY%3D Occurrence Handle7233950

    CAS  PubMed  Google Scholar 

  14. M Schlumberger F Vathaire ParticleDe JP Travagli et al. (1987) ArticleTitleDifferentiated thyroid carcinoma in childhood: long-term follow-up of 72 patients J. Clin. Endocrinol. Metab. 65 1088–1094 Occurrence Handle1:STN:280:BieD2MbkvFQ%3D Occurrence Handle3680475

    CAS  PubMed  Google Scholar 

  15. Conard RA. Late radiation effects in Marshall Islanders exposed to fallout 28 years ago. In Boice JD Jr, Fraumeni JF Jr, editors, Radiation Carcinogenesis: Epidemiology and Biological Significance, New York, Raven, 1984;57–71

  16. Akiba S, Lubin J, Ezaki H, et al. Thyroid Cancer Incidence among Atomic Bomb Survivors in Hiroshima and Nagasaki, 1958-1979b (Technical Report TR 5-91). Hiroshima, Radiation Effects Research Foundation, 1991

  17. Viswanathan K, Gierlowski TC, Schneider AB. Children thyroid cancer: characteristics and long-term outcome in children irradiated for benign conditions of the head and neck. Arch. Pediatr. Adolesc. Med. 1994;1948:260

  18. Oleynic VA, Cheban AK. Thyroid cancer in children of Ukraine from 1981 to 1992. In Robbins J, editor, Treatment of Thyroid Cancer in Childhood, Bethesda, National Institutes of Health, 1994;45-4919. Astakhova LN, Vorontsova TV, Arozd VM. Thyroid nodule pathology in children of the Republic of Belarus following the Chernobyl accident. In Robbins J, editor, Treatment of Thyroid Cancer in Childhood, Bethesda, National Institutes of Health, 1994;35-39

  19. HH Storm I Plesko (2001) ArticleTitleSurvival of children with thyroid cancer in Europe 1978-1989 Eur. J. Cancer 37 775–779 Occurrence Handle10.1016/S0959-8049(01)00010-7 Occurrence Handle1:STN:280:DC%2BD3M3itF2ntQ%3D%3D Occurrence Handle11311653

    Article  CAS  PubMed  Google Scholar 

  20. P Verger O Catelinois M Tirmarche et al. (2003) ArticleTitleThyroid cancers in France and the Chernobyl accident: risk assessment and recommendations for improving epidemiological knowledge Health Phys. 85 323–329 Occurrence Handle10.1097/00004032-200309000-00008 Occurrence Handle1:CAS:528:DC%2BD3sXlvF2qt70%3D Occurrence Handle12938722

    Article  CAS  PubMed  Google Scholar 

  21. P Jacob G Goulko WF Heidenreich et al. (1998) ArticleTitleThyroid cancer risk to children calculated Nature 392 31–32 Occurrence Handle10.1038/32076 Occurrence Handle1:CAS:528:DyaK1cXhvVOhs7Y%3D Occurrence Handle9510245

    Article  CAS  PubMed  Google Scholar 

  22. SJ Rybakov IV Komissarenko ND Tronko et al. (2000) ArticleTitleThyroid cancer in children of Ukraine after the Chernobyl accident World J. Surg. 24 1446–1449 Occurrence Handle10.1007/s002680010239 Occurrence Handle1:STN:280:DC%2BD3M%2FlslKntQ%3D%3D Occurrence Handle11038221

    Article  CAS  PubMed  Google Scholar 

  23. M Rahu (2003) ArticleTitleHealth effects of the Chernobyl accident: fears, rumours, and the truth Eur. J. Cancer 39 295–299 Occurrence Handle10.1016/S0959-8049(02)00764-5 Occurrence Handle12565980

    Article  PubMed  Google Scholar 

  24. KB Moysich RJ Menezes AM Michalek (2002) ArticleTitleChernobyl-related ionising radiation exposure and cancer risk: an epidemiological review Lancet Oncol. 3 269–279 Occurrence Handle10.1016/S1470-2045(02)00727-1 Occurrence Handle12067803

    Article  PubMed  Google Scholar 

  25. RJ Jackson DM DeLozier G Gerasimov et al. (2002) ArticleTitleChernobyl and iodine deficiency in the Russian Federation: an environmental disaster leading to a public health opportunity J. Public Health Policy 23 453–470 Occurrence Handle12532684

    PubMed  Google Scholar 

  26. HM Rabes EP Demidchik JD Sidorow et al. (2000) ArticleTitlePattern of radiation-induced RET and NTRK1 rearrangements in 191 post-Chernobyl papillary thyroid carcinomas: biological, phenotypic, and clinical implications Clin. Cancer Res. 6 1093–1103 Occurrence Handle1:CAS:528:DC%2BD3cXisVaqu7Y%3D Occurrence Handle10741739

    CAS  PubMed  Google Scholar 

  27. R Elisei C Romei T Vorontsova et al. (2001) ArticleTitleRET/PTC rearrangements in thyroid nodules: studies in irradiated and not irradiated, malignant and benign thyroid lesions in children and adults J. Clin. Endocrinol. Metab. 86 3211–3216

    Google Scholar 

  28. CL Fenton Y Lukes D Nicholson et al. (2000) ArticleTitleThe ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults J. Clin. Endocrinol. Metab. 85 1170–1175

    Google Scholar 

  29. O Alsanea N Wata K Ain et al. (2000) ArticleTitleIs familial non-medullary thyroid carcinoma more aggressive than sporadic thyroid cancer? A multicenter series Surgery 128 1043–1050 Occurrence Handle10.1067/msy.2000.110848 Occurrence Handle1:STN:280:DC%2BD3M%2FnsFehtA%3D%3D Occurrence Handle11114641

    Article  CAS  PubMed  Google Scholar 

  30. F Canzian P Amati HR Harach et al. (1998) ArticleTitleA gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2 Am. J. Hum. Genet. 63 1743–1748 Occurrence Handle10.1086/302164 Occurrence Handle1:CAS:528:DyaK1MXlt1Sjtw%3D%3D Occurrence Handle9837827

    Article  CAS  PubMed  Google Scholar 

  31. CD Malchoff M Sarfarazi B Tendler et al. (2000) ArticleTitlePapillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome J. Clin. Endocrinol. Metab. 85 1758–1764

    Google Scholar 

  32. RT Kirkland JL Kirkland HS Rosenberg (1973) ArticleTitleSolitary thyroid nodules in 30 children and report of a child with a thyroid abscess Pediatrics 51 85 Occurrence Handle1:STN:280:CSyD1crjtFI%3D Occurrence Handle4684450

    CAS  PubMed  Google Scholar 

  33. JK Harness NW Thompson RH Nishiyama (1971) ArticleTitleChildhood thyroid carcinoma Arch. Surg. 102 278 Occurrence Handle1:STN:280:CS6C28zjvVw%3D Occurrence Handle4324199

    CAS  PubMed  Google Scholar 

  34. CL Fowler WJ Pokorny FJ Harberg (1989) ArticleTitleThyroid nodules in children: current profile of changing disease South. Med. J. 82 1472 Occurrence Handle1:STN:280:By%2BD1cvmt1M%3D Occurrence Handle2688127

    CAS  PubMed  Google Scholar 

  35. A Corrias S Einaudi E Chiorboli et al. (2001) ArticleTitleAccuracy of fine-needle aspiration biopsy of thyroid nodules in detecting malignancy in childhood: comparison with conventional clinical, laboratory, and imaging approaches J. Clin. Endocrinol. Metab. 86 4644–4648 Occurrence Handle10.1210/jc.86.10.4644 Occurrence Handle1:CAS:528:DC%2BD3MXptVaku7g%3D Occurrence Handle11600519

    Article  CAS  PubMed  Google Scholar 

  36. D Zimmerman ID Hay IR Gough et al. (1988) ArticleTitlePapillary thyroid carcinoma in children and adults: long-term follow-up of 1039 patients conservatively treated at one institution during three decades Surgery 104 1157–1166 Occurrence Handle1:STN:280:BiaD2MfotFM%3D Occurrence Handle3194843

    CAS  PubMed  Google Scholar 

  37. MP LaQuaglia MT Corbally G Heller et al. (1988) ArticleTitleRecurrence and morbidity in differentiated thyroid carcinoma in children Surgery 104 1149–1156 Occurrence Handle1:STN:280:BiaD2MfotFI%3D Occurrence Handle3194842

    CAS  PubMed  Google Scholar 

  38. HG Suarez (1998) ArticleTitleGenetic alterations in human epithelial thyroid tumours Clin. Endocrinol. (Oxf.) 48 531–546 Occurrence Handle10.1046/j.1365-2265.1998.00443.x Occurrence Handle1:CAS:528:DyaK1cXjs12rtro%3D

    Article  CAS  Google Scholar 

  39. NR Farid M Zou Y Shi (1995) ArticleTitleGenetics of follicular thyroid cancer Endocrinol. Metab. Clin. North Am. 24 865–883 Occurrence Handle1:CAS:528:DyaK28XlvFOgug%3D%3D Occurrence Handle8608782

    CAS  PubMed  Google Scholar 

  40. TG Kroll P Sarraf L Pecciarini et al. (2000) ArticleTitlePAX8-PPARγ1 fusion oncogene in human thyroid carcinoma Science 289 1357–1360 Occurrence Handle10.1126/science.289.5483.1357 Occurrence Handle1:CAS:528:DC%2BD3cXmt1amsbw%3D Occurrence Handle10958784

    Article  CAS  PubMed  Google Scholar 

  41. Beahrs OH, Henson DE, Hutter RVP, et al. Manual for Staging of Cancer, Philadelphia, Lippincott, 1992

  42. Fleming ID, Cooper JS, Henson DE, et al, editors. AJCC Cancer Staging Manual, Philadelphia, Lippincott-Raven, 1997

  43. ID Hay WM McConahey JR Goellner (2002) ArticleTitleManaging patients with papillary thyroid carcinoma: insights gained from the Mayo Clinic’s experience of treating 2,512 consecutive patients during 1940 through 2000 Trans. Am. Clin. Climatol. Assoc. 113 241–260 Occurrence Handle12053713

    PubMed  Google Scholar 

  44. ID Hay EJ Bergstralh JR Goellner et al. (1993) ArticleTitlePredicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1,779 patients surgically treated at one institution during 1940 through 1989 Surgery 114 1050–1058 Occurrence Handle1:STN:280:ByuD2sfisVI%3D Occurrence Handle8256208

    CAS  PubMed  Google Scholar 

  45. ID Hay GB Thompson CS Grant et al. (2002) ArticleTitlePapillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940-1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients World J. Surg. 26 879–885 Occurrence Handle10.1007/s00268-002-6612-1 Occurrence Handle12016468

    Article  PubMed  Google Scholar 

  46. JL Hamburger (1994) ArticleTitleDiagnosis of thyroid nodules by fine needle biopsy: use and abuse J. Clin. Endocrinol. Metab. 79 335–339 Occurrence Handle10.1210/jc.79.2.335 Occurrence Handle1:STN:280:ByuA387ksVY%3D Occurrence Handle8045944

    Article  CAS  PubMed  Google Scholar 

  47. H Gharib (1997) ArticleTitleChanging concepts in the diagnosis and management of thyroid nodules Endocrinol. Metab. Clin. North Am. 26 7777–7800

    Google Scholar 

  48. RL Nelson HW Wahaner CA Gorman (1978) ArticleTitleRectilinear thyroid scanning as a predictor of malignancy Ann. Intern. Med. 88 41–44 Occurrence Handle1:STN:280:CSeD2sfpvVI%3D Occurrence Handle619756

    CAS  PubMed  Google Scholar 

  49. FC Hughes M Bauden H Laccourreye (1989) ArticleTitleLe nodule thyroidien: une étude rétrospective de 200 observations Ann. Otolaryngol. Chir. Cervicofac. 106 77–81 Occurrence Handle2665608

    PubMed  Google Scholar 

  50. A Paphavasit GB Thompson ID Hay et al. (1997) ArticleTitleFollicular and Hürthle cell thyroid neoplasms: is frozen section evaluation worthwhile? Arch. Surg. 132 674–679

    Google Scholar 

  51. JW Haveman KM Tol Particlevan CW Rouwe et al. (2003) ArticleTitleSurgical experience in children with differentiated thyroid carcinoma Ann. Surg. Oncol. 10 15–20 Occurrence Handle10.1245/ASO.2003.03.002 Occurrence Handle12513954

    Article  PubMed  Google Scholar 

  52. LP Kowalski JG Filho CAL Pinto et al. (2003) ArticleTitleLong-term survival rates in young patients with thyroid carcinoma Arch. Otolaryngol. Head Neck Surg. 129 746–749 Occurrence Handle10.1001/archotol.129.7.746 Occurrence Handle12874076

    Article  PubMed  Google Scholar 

  53. D Giuffrida C Scollo G Pellegriti et al. (2002) ArticleTitleDifferentiated thyroid cancer in children and adolescents J. Endocrinol. Invest. 25 18–24 Occurrence Handle11883862

    PubMed  Google Scholar 

  54. C Arici O Erdogan H Altunbas et al. (2002) ArticleTitleDifferentiated thyroid carcinoma in children and adolescents: clinical characteristics, treatment and outcome of 15 patients Horm. Res. 57 153–156 Occurrence Handle10.1159/000058375 Occurrence Handle1:CAS:528:DC%2BD38XksVygsbs%3D Occurrence Handle12053086

    Article  CAS  PubMed  Google Scholar 

  55. PW Grigsby A Gal-or JM Michalski et al. (2002) ArticleTitleChildhood and adolescent thyroid carcinoma Cancer 95 724–729 Occurrence Handle10.1002/cncr.10725 Occurrence Handle12209714

    Article  PubMed  Google Scholar 

  56. MWB Arush ME Stein MP Nahum et al. (2000) ArticleTitlePediatric thyroid carcinoma: 22 years of experience at the Northern Israel Oncology Center (1973-1995) Pediatr. Hematol. Oncol. 17 875–892

    Google Scholar 

  57. JS Brink JA Heerden Particlevan B McIver et al. (2000) ArticleTitlePapillary thyroid cancer with pulmonary metastases in children: long-term prognosis Surgery 128 881–887 Occurrence Handle10.1067/msy.2000.109728 Occurrence Handle1:STN:280:DC%2BD3M%2FnsFegtA%3D%3D Occurrence Handle11114619

    Article  CAS  PubMed  Google Scholar 

  58. B Jarzab DH Junak J Wloch et al. (2000) ArticleTitleMultivariate analysis of prognostic factors for differentiated thyroid carcinoma in children Eur. J. Nucl. Med. 27 833–841 Occurrence Handle10.1007/s002590000271 Occurrence Handle1:STN:280:DC%2BD3M%2Fot1aqsA%3D%3D Occurrence Handle10952495

    Article  CAS  PubMed  Google Scholar 

  59. D Landau L Vini R Ahern et al. (2000) ArticleTitleThyroid cancer in children: the Royal Marsden Hospital experience Eur. J. Cancer 36 214–220 Occurrence Handle10.1016/S0959-8049(99)00281-6 Occurrence Handle1:STN:280:DC%2BD3c3gsFCmsQ%3D%3D Occurrence Handle10741280

    Article  CAS  PubMed  Google Scholar 

  60. MP LaQuaglia T Black GW Holcomb SuffixIII et al. (2000) ArticleTitleDifferentiated thyroid cancer: clinical characteristics, treatment, and outcome in patients under 21 years of age who present with distant metastases: a report from the Surgical Discipline Committee of the Children’s Cancer Group J. Pediatr. Surg. 35 955–960 Occurrence Handle10.1053/jpsu.2000.6935 Occurrence Handle10873043

    Article  PubMed  Google Scholar 

  61. CAW Dinauer RM Tuttle DK Robie et al. (1997) ArticleTitleClinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents and young adults Clin. Endocrinol. (Oxf.) 49 619–628 Occurrence Handle10.1046/j.1365-2265.1998.00584.x

    Article  Google Scholar 

  62. KD Newman T Black G Heller et al. (1998) ArticleTitleDifferentiated thyroid cancer: determinants of disease progression in patients < 21 years of age at diagnosis: a report from the Surgical Discipline Committee of the Children’s Cancer Group Ann. Surg. 227 533–541 Occurrence Handle10.1097/00000658-199804000-00014 Occurrence Handle1:STN:280:DyaK1c3itlSjtA%3D%3D Occurrence Handle9563542

    Article  CAS  PubMed  Google Scholar 

  63. K Segald J Shvero Y Stern et al. (1998) ArticleTitleSurgery of thyroid cancer in children and adolescents Head Neck 20 293–297 Occurrence Handle10.1002/(SICI)1097-0347(199807)20:4<293::AID-HED2>3.0.CO;2-U Occurrence Handle1:STN:280:DyaK1c3kvVWitg%3D%3D Occurrence Handle9588700

    Article  CAS  PubMed  Google Scholar 

  64. R Vassilopoulou-Sellin H Goepfert B Raney et al. (1998) ArticleTitleDifferentiated thyroid cancer in children and adolescents: clinical outcome and mortality after long-term follow-up Head Neck 20 549–555 Occurrence Handle10.1002/(SICI)1097-0347(199809)20:6<549::AID-HED10>3.0.CO;2-R Occurrence Handle1:STN:280:DyaK1czmsl2hsg%3D%3D Occurrence Handle9702543

    Article  CAS  PubMed  Google Scholar 

  65. R Vassilopoulou-Sellin PN Schultz TP Haynie (1996) ArticleTitleClinical outcome of patients with papillary thyroid carcinoma who have recurrence after initial radioactive iodine therapy Cancer 78 493–501 Occurrence Handle10.1002/(SICI)1097-0142(19960801)78:3<493::AID-CNCR17>3.0.CO;2-U Occurrence Handle1:STN:280:BymA38%2FlvVQ%3D Occurrence Handle8697396

    Article  CAS  PubMed  Google Scholar 

  66. P Singer DS Cooper GH Daniels (1996) ArticleTitleTreatment guidelines for the management of thyroid carcinoma Arch. Intern. Med. 156 2165–2172 Occurrence Handle10.1001/archinte.156.19.2165 Occurrence Handle1:STN:280:ByiD2c%2FltVU%3D Occurrence Handle8885814

    Article  CAS  PubMed  Google Scholar 

  67. ID Hay S Feld M Garcia (1997) ArticleTitleAACE clinical practice guidelines for the management of thyroid carcinoma Endocr. Pract. 3 60–71

    Google Scholar 

  68. AR Shaha RM Byers JJ Terz (1997) ArticleTitleThyroid cancer surgical practice guidelines: scope and format of guidelines Oncology 11 1228–1234 Occurrence Handle9268983

    PubMed  Google Scholar 

  69. InstitutionalAuthorNameThyroid Carcinoma Task Force (2001) ArticleTitleAACE/AAES medical/surgical guidelines for clinical practice: management of thyroid carcinoma Endocr. Pract. 7 202–221

    Google Scholar 

  70. EL Mazzaferri (1999) ArticleTitleNCCN thyroid carcinoma practice guidelines Oncology 13 391–416

    Google Scholar 

  71. GFW Scheumann H Seeliger TJ Musholt et al. (1996) ArticleTitleCompletion thyroidectomy in 131 patients with differentiated thyroid carcinoma Acta Chir. 162 677–684 Occurrence Handle1:STN:280:ByiD28vovFM%3D

    CAS  Google Scholar 

  72. LM McGregor PM Rosoff (2001) ArticleTitleFollicle-derived thyroid cancer in young people: the Duke experience Pediatr. Hematol. Oncol. 18 89–100 Occurrence Handle10.1080/088800101300002919 Occurrence Handle1:STN:280:DC%2BD3MvitF2muw%3D%3D Occurrence Handle11255738

    Article  CAS  PubMed  Google Scholar 

  73. MA Skinner (2001) ArticleTitleCancer of the thyroid gland in infants and children Semin. Pediatr. Surg. 10 119–126 Occurrence Handle10.1053/spsu.2001.24697 Occurrence Handle1:STN:280:DC%2BD3Mvjtl2ksQ%3D%3D Occurrence Handle11481648

    Article  CAS  PubMed  Google Scholar 

  74. ID Hay CS Grant EJ Bergstralh et al. (1998) ArticleTitleUnilateral total lobectomy: is it sufficient surgical treatment for patients with AMES low-risk papillary thyroid carcinoma? Surgery 124 958–966 Occurrence Handle10.1067/msy.1998.91825 Occurrence Handle1:STN:280:DyaK1M%2FntFOgsQ%3D%3D Occurrence Handle9854569

    Article  CAS  PubMed  Google Scholar 

  75. ID Hay CS Grant JA Heerden Particlevan et al. (1992) ArticleTitlePapillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period Surgery 112 1139–1147 Occurrence Handle1:STN:280:ByyD1cfhs1M%3D Occurrence Handle1455316

    CAS  PubMed  Google Scholar 

  76. ID Hay (1990) ArticleTitlePapillary thyroid carcinoma Endocrinol. Metab. Clin. North Am. 19 545–576 Occurrence Handle1:STN:280:By6D1crktlE%3D Occurrence Handle2261906

    CAS  PubMed  Google Scholar 

  77. WM McConahey ID Hay LB Woolner et al. (1986) ArticleTitlePapillary thyroid cancer treated at the Mayo Clinic, 1946 through 1970: initial manifestations, pathologic findings, therapy and outcome Mayo Clin. Proc. 61 978–996 Occurrence Handle1:STN:280:BiiD3sfhvFc%3D Occurrence Handle3773569

    CAS  PubMed  Google Scholar 

  78. SA Jong ParticleDe JG Demeter AM Lawrence et al. (1992) ArticleTitleNecessity and safety of completion thyroidectomy for differentiated thyroid carcinoma Surgery 112 734–739 Occurrence Handle1411945

    PubMed  Google Scholar 

  79. WH Beierwaltes (1978) ArticleTitleThe treatment of thyroid carcinoma with radioactive iodine Semin. Nucl. Med. 8 79–94 Occurrence Handle1:STN:280:CSeC3sfnsVc%3D Occurrence Handle345448

    CAS  PubMed  Google Scholar 

  80. SB Paryani RJ Chobe W Scott et al. (1996) ArticleTitleManagement of thyroid carcinoma with radioactive 131I Int. J. Radiat. Oncol. Biol. Phys. 36 S83–S86 Occurrence Handle10.1016/S0360-3016(96)00245-3

    Article  Google Scholar 

  81. AWG Goolden (1988) ArticleTitleThe use of radioactive iodine in thyroid carcinoma Eur. J. Cancer Clin. Oncol. 24 339–343 Occurrence Handle10.1016/0277-5379(88)90277-5 Occurrence Handle1:STN:280:BieC1crktVc%3D Occurrence Handle3281849

    Article  CAS  PubMed  Google Scholar 

  82. JB Gorlin SE Sallen (1990) ArticleTitleThyroid cancer in childhood Endocrinol. Metab. Clin. North Am. 19 649–662 Occurrence Handle1:STN:280:By6D1crksVQ%3D Occurrence Handle2261910

    CAS  PubMed  Google Scholar 

  83. JG Desjardins J Bass G Leboeuf et al. (1988) ArticleTitleA twenty-year experience with thyroid carcinoma in children J. Pediatr. Surg. 23 709–713 Occurrence Handle1:STN:280:BiaD3M7islQ%3D Occurrence Handle3171838

    CAS  PubMed  Google Scholar 

  84. DR McClellan GL Francis (1996) ArticleTitleThyroid cancer in children, pregnant women, and patients with Graves’ disease Endocrinol. Metab. Clin. North Am. 25 27–48 Occurrence Handle1:STN:280:ByiD28zotFY%3D Occurrence Handle8907679

    CAS  PubMed  Google Scholar 

  85. CA Welch Dinauer RM Tuttle DK Robie et al. (1998) ArticleTitleClinical features associated with metastasis and recurrence of differentiated thyroid cancer in children, adolescents, and young adults Clin. Endocrinol. (Oxf.) 49 619–628 Occurrence Handle10.1046/j.1365-2265.1998.00584.x Occurrence Handle1:STN:280:DyaK1M3ht1yhtQ%3D%3D

    Article  CAS  Google Scholar 

  86. AJ Sykes HR Gattamanen (1997) ArticleTitleCarcinoma of the thyroid in children: a 25-year experience Med. Pediatr. Oncol. 29 103–107 Occurrence Handle10.1002/(SICI)1096-911X(199708)29:2<103::AID-MPO7>3.0.CO;2-I Occurrence Handle1:STN:280:ByiA38votVI%3D Occurrence Handle9180911

    Article  CAS  PubMed  Google Scholar 

  87. AS Fassina M Rupolo MR Pelizzo et al. (1994) ArticleTitleThyroid cancer in children and adolescents Tumori 80 257–262 Occurrence Handle1:STN:280:ByqD28rhs1U%3D Occurrence Handle7974795

    CAS  PubMed  Google Scholar 

  88. D Danese A Gardini A Farsetti et al. (1997) ArticleTitleThyroid carcinoma in children and adolescents Eur. J. Pediatr. 156 190–194 Occurrence Handle10.1007/s004310050580 Occurrence Handle1:STN:280:ByiB3sjisl0%3D Occurrence Handle9083757

    Article  CAS  PubMed  Google Scholar 

  89. ME Dottorini A Vignati L Mazzucchelli et al. (1997) ArticleTitleDifferentiated thyroid carcinoma in children and adolescents: a 37-year experience in 85 patients J. Nucl. Med. 38 669–675 Occurrence Handle1:STN:280:ByiA3MvgvVc%3D Occurrence Handle9170425

    CAS  PubMed  Google Scholar 

  90. SD Yeh MP Quaglia ParticleLa (1997) ArticleTitle131I therapy for pediatric thyroid cancer Semin. Pediatr. Surg. 6 128–133 Occurrence Handle1:STN:280:ByiH3cfotFE%3D Occurrence Handle9263334

    CAS  PubMed  Google Scholar 

  91. RK Jeevanram DH Shah SM Sharma et al. (1986) ArticleTitleInfluence of initial large dose on subsequent uptake of therapeutic radioiodine in thyroid cancer patients Int. J. Radiat. Appl. Instrum. B 13 277–279 Occurrence Handle1:STN:280:BiiD3szgt1w%3D

    CAS  Google Scholar 

  92. HM Park OW Perkins JW Edmondson et al. (1994) ArticleTitleInfluence of diagnostic radioiodine in the uptake of ablative dose iodine-131 Thyroid 4 49–54 Occurrence Handle1:STN:280:ByuA3s7pvFA%3D Occurrence Handle8054861

    CAS  PubMed  Google Scholar 

  93. JP Muratet A Daver JF Minier (1998) ArticleTitleInfluence of scanning doses of iodine-131 on subsequent first ablative treatment outcome in patients operated on for differentiated thyroid carcinoma J. Nucl. Med. 39 1546–1550 Occurrence Handle1:CAS:528:DyaK1cXmtlyhsrw%3D Occurrence Handle9744340

    CAS  PubMed  Google Scholar 

  94. JC Reynolds (1997) ArticleTitlePercent 131I uptake and post-therapy 131I scans: their role in the management of thyroid cancer Thyroid 7 281–284 Occurrence Handle1:STN:280:ByiB2sbhvFc%3D Occurrence Handle9133701

    CAS  PubMed  Google Scholar 

  95. M Schlumberger O Arcangioli JD Piekarski et al. (1988) ArticleTitleDetection and treatment of lung metastases of differentiated thyroid carcinoma in patients with normal chest x-rays J. Nucl. Med. 29 1790–1794 Occurrence Handle1:STN:280:BiaD3snktVY%3D Occurrence Handle3183748

    CAS  PubMed  Google Scholar 

  96. S Diederich H Lenzen (2000) ArticleTitleRadiation exposure associated with imaging of the chest: comparison of different radiographic and computed tomography techniques Cancer 89 2457–2460 Occurrence Handle10.1002/1097-0142(20001201)89:11+<2457::AID-CNCR22>3.3.CO;2-Z Occurrence Handle1:STN:280:DC%2BD3M%2FnvFelsA%3D%3D Occurrence Handle11147626

    Article  CAS  PubMed  Google Scholar 

  97. Snyder WS, Ford MR, Warner GG, et al. “S,” Absorbed Dose per Unit Cumulated Activity for Selected Radionuclides and Organs, MIRD (Medical Internal Radiation Dose Committee) Pamphlet 11, Reston, VA, Society of Nuclear Medicine, 1975

  98. Loevinger R, Berman M. A Revised Schema for Absorbed-dose Calculations for Biologically Distributed Radionuclides. MIRD (Medical Internal Radiation Dose Committee) Pamphlet 1—Revised, Reston, VA, Society of Nuclear Medicine, 1976

  99. EL Mazzaferri (1999) ArticleTitleAn overview of the management of papillary and follicular thyroid carcinoma Thyroid 9 421–428 Occurrence Handle1:STN:280:DyaK1M3ptFOqsQ%3D%3D Occurrence Handle10365671

    CAS  PubMed  Google Scholar 

  100. SAR Doi NJY Woodhouse (2000) ArticleTitleAblation of thyroid remnant and 131I dose in differentiated thyroid cancer Clin. Endocrinol. (Oxf.) 52 765–773 Occurrence Handle10.1046/j.1365-2265.2000.01014.x Occurrence Handle1:STN:280:DC%2BD3czgslGlsA%3D%3D

    Article  CAS  Google Scholar 

  101. J Robbins MJ Merino JD Boice et al. (1991) ArticleTitleThyroid cancer: a lethal endocrine neoplasm Ann. Intern. Med. 115 133–147 Occurrence Handle1:STN:280:By6B1c3hvFY%3D Occurrence Handle2058861

    CAS  PubMed  Google Scholar 

  102. JD Pineda T Lee K Ain et al. (1995) ArticleTitleIodine-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative diagnostic scan J. Clin. Endocrinol. Metab. 80 1488–1492 Occurrence Handle10.1210/jc.80.5.1488 Occurrence Handle1:CAS:528:DyaK2MXlsV2rsrc%3D Occurrence Handle7744991

    Article  CAS  PubMed  Google Scholar 

  103. J Robbins (1999) ArticleTitleManagement of thyroglobulin-positive, body scan-negative thyroid cancer patients: evidence for utility of I-131 therapy J. Endocrinol. Invest. 22 808–810 Occurrence Handle1:STN:280:DC%2BD3c%2FotVWksg%3D%3D Occurrence Handle10614533

    CAS  PubMed  Google Scholar 

  104. F Pacini L Agate R Elisei et al. (2001) ArticleTitleOutcome of differentiated thyroid cancer with detectable serum TG and negative diagnostic 131I whole body scan: comparison of patients treated with high 131I activities versus untreated patients J. Clin. Endocrinol. Metab. 86 4092–4097

    Google Scholar 

  105. HR Maxon (1999) ArticleTitleQuantitative radioiodine therapy in the treatment of differentiated thyroid cancer Q. J. Nucl. Med. 43 313–323 Occurrence Handle1:STN:280:DC%2BD3c7ps1egsw%3D%3D Occurrence Handle10731782

    CAS  PubMed  Google Scholar 

  106. RS Benua NR Cicale M Sonenberg (1962) ArticleTitleer al. The relation of radioiodine dosimetry to results and complications in the treatment of metastatic thyroid cancer AJR Am. J. Roentgenol. 87 171–186 Occurrence Handle1:STN:280:CC2D3cfmslA%3D

    CAS  Google Scholar 

  107. D Nostrand ParticleVan J Neutze F Atkins (1986) ArticleTitleSide effects of “rational dose” iodine-131 therapy for metastatic well-differentiated thyroid carcinoma J. Nucl. Med. 27 1519–1527 Occurrence Handle3760975

    PubMed  Google Scholar 

  108. WH Beierwaltes RH Nishiyama NW Thompson et al. (1982) ArticleTitleSurvival time and “cure” in papillary and follicular thyroid carcinoma with distant metastases: statistics following University of Michigan therapy J. Nucl. Med. 25 561–568

    Google Scholar 

  109. M Schlumberg F Mancusi E Baudin et al. (1997) ArticleTitle131I therapy for elevated thyroglobulin levels Thyroid 7 273–276 Occurrence Handle1:STN:280:ByiB2sbhvFU%3D Occurrence Handle9133699

    CAS  PubMed  Google Scholar 

  110. BL Li J Hu XF Want et al. (1990) ArticleTitlePrognostic significance of general immune competence in acute leukemia Med. Oncol. Tumor Pharmacother. 7 233–239 Occurrence Handle1:CAS:528:DyaK3MXisFSgtL0%3D Occurrence Handle2283891

    CAS  PubMed  Google Scholar 

  111. G Doria G Biozzi D Mouton et al. (1997) ArticleTitleGenetic control of immune responsiveness, aging and tumor incidence Mech. Aging Dev. 96 1–13

    Google Scholar 

  112. S Gupta A Patel A Folstad et al. (2001) ArticleTitleInfiltration of differentiated thyroid carcinoma by proliferating lymphocytes is associated with improved disease-free survival for children and young adults J. Clin. Endocrinol. Metab. 86 1346–1354

    Google Scholar 

  113. J Modi A Patel R Terrell et al. (2003) ArticleTitlePapillary thyroid carcinomas from young adults and children contain a mixture of lymphocytes J. Clin. Endocrinol. Metab. 88 4418–4425 Occurrence Handle10.1210/jc.2003-030342 Occurrence Handle1:CAS:528:DC%2BD3sXntlagsb8%3D Occurrence Handle12970319

    Article  CAS  PubMed  Google Scholar 

  114. EL Mazzaferri RT Kloos (2000) ArticleTitleUsing recombinant human TSH in the management of well-differentiated thyroid cancer: current strategies and future direction Thyroid 10 767–778 Occurrence Handle1:CAS:528:DC%2BD3cXos1Oktr8%3D Occurrence Handle11041454

    CAS  PubMed  Google Scholar 

  115. C Menzel F Grunwald A Schomburg et al. (1996) ArticleTitleHigh-dose” radioiodine therapy in advanced differentiated thyroid carcinoma J. Nucl. Med. 37 1496–1503 Occurrence Handle1:CAS:528:DyaK28XlvF2msbY%3D Occurrence Handle8790201

    CAS  PubMed  Google Scholar 

  116. JC Sisson (1989) ArticleTitleMedical treatment of benign and malignant thyroid tumors Endocrinol. Metab. Clin. North Am. 18 359–387 Occurrence Handle1:STN:280:BiaA3crltl0%3D Occurrence Handle2663479

    CAS  PubMed  Google Scholar 

  117. CJ Edmonds T Smith (1986) ArticleTitleThe long-term hazards of the treatment of thyroid cancer with radioiodine Br. J. Radiol. 59 45–51

    Google Scholar 

  118. M Schlumberger F Vathaire Particlede C Ceccarelli et al. (1996) ArticleTitleExposure to radioactive iodine-131 for scintigraphy or therapy does not preclude pregnancy in thyroid cancer patients J. Nucl. Med. 37 606–612 Occurrence Handle1:CAS:528:DyaK28XislKlurc%3D Occurrence Handle8691249

    CAS  PubMed  Google Scholar 

  119. S Winters S Berga (1997) ArticleTitleGonadal dysfunction in patients with thyroid disorders Endocrinologist 7 167–173

    Google Scholar 

  120. PW Wang ST Wang RT Liu et al. (1999) ArticleTitleLevothyroxine suppression of thyroglobulin in patients with differentiated thyroid carcinoma J. Clin. Endocrinol. Metab. 84 4549–4553 Occurrence Handle10.1210/jc.84.12.4549 Occurrence Handle1:CAS:528:DyaK1MXotVGqsrc%3D Occurrence Handle10599717

    Article  CAS  PubMed  Google Scholar 

  121. MD Ringel PL Balducci-Silano JS Anderson et al. (1999) ArticleTitleQuantitative reverse transcription-polymerase chain reaction of circulating thyroglobulin messenger ribonucleic acid for monitoring patients with thyroid carcinoma J. Clin. Endocrinol. Metab. 84 4037–4042 Occurrence Handle10.1210/jc.84.11.4037 Occurrence Handle1:CAS:528:DyaK1MXntlOqtb0%3D Occurrence Handle10566646

    Article  CAS  PubMed  Google Scholar 

  122. ME O’Connell RP Ahern CL Harmer (1994) ArticleTitleResults of external beam radiotherapy in differentiated thyroid carcinoma: a retrospective study from the Royal Marsden Hospital Eur. J. Cancer 30A 733–739 Occurrence Handle10.1016/0959-8049(94)90284-4 Occurrence Handle1:STN:280:ByqD3c%2FpsVU%3D Occurrence Handle7917529

    Article  CAS  PubMed  Google Scholar 

  123. R Mazzarotto MG Cesaro O Lora et al. (2000) ArticleTitleThe role of external beam radiotherapy in the management of differentiated thyroid cancer Biomed. Pharmacother. 54 345–349 Occurrence Handle10.1016/S0753-3322(00)80061-X Occurrence Handle1:STN:280:DC%2BD3cvkt1ShtA%3D%3D Occurrence Handle10989971

    Article  CAS  PubMed  Google Scholar 

  124. JD Brierley RW Tsang (1999) ArticleTitleExternal-beam radiation therapy in the treatment of differentiated thyroid cancer Semin. Surg. Oncol. 16 42–49 Occurrence Handle10.1002/(SICI)1098-2388(199901/02)16:1<42::AID-SSU8>3.0.CO;2-4 Occurrence Handle1:STN:280:DyaK1M7gsFOntw%3D%3D Occurrence Handle9890739

    Article  CAS  PubMed  Google Scholar 

  125. K Shimaoka DA Schoenffeld WD DeWys et al. (1985) ArticleTitleA randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma Cancer 56 2155–2160

    Google Scholar 

  126. P Besi ParticleDe B Busnardo S Toso et al. (1991) ArticleTitleCombined chemotherapy with bleomycin, adriamycin, and platinum in advanced thyroid cancer J. Endocrinol. Invest. 14 475–480 Occurrence Handle1723086

    PubMed  Google Scholar 

  127. JH Kim RD Leeper (1983) ArticleTitleTreatment of anaplastic giant and spindle cell carcinoma of the thyroid gland with combination adriamycin and radiation therapy: a new approach Cancer 52 954–960 Occurrence Handle1:STN:280:BiyB1cvnsFQ%3D Occurrence Handle6883279

    CAS  PubMed  Google Scholar 

  128. KB Ain S Tofiq KD Taylor (1996) ArticleTitleAntineoplastic activity of taxol against human anaplastic thyroid carcinoma cell lines in vitro and in vivo J. Clin. Endocriniol. Metab. 81 3650–3653 Occurrence Handle10.1210/jc.81.10.3650 Occurrence Handle1:CAS:528:DyaK28XmtlCmtbs%3D

    Article  CAS  Google Scholar 

  129. G Xu J Pan C Martin et al. (2001) ArticleTitleAngiogenesis inhibition in the in vivo antineoplastic effect of manumycin and paclitaxel against anaplastic thyroid carcinoma J. Clin. Endocrinol. Metab. 86 1769–1777

    Google Scholar 

  130. AM Straight A Patel C Fenton et al. (2002) ArticleTitleThyroid carcinomas that express telomerase follow a more aggressive clinical course in children and adolescents J. Endocrinol. Invest. 25 302–308 Occurrence Handle1:CAS:528:DC%2BD38XktlWiurY%3D Occurrence Handle12030599

    CAS  PubMed  Google Scholar 

  131. A Patel S Jhiang S Dogra et al. (2002) ArticleTitleDifferentiated thyroid carcinoma that express sodium-iodide symporter have a lower risk of recurrence for children and adolescents Pediatr. Res. 52 737–744 Occurrence Handle10.1203/01.PDR.0000031920.28469.B8 Occurrence Handle1:CAS:528:DC%2BD38XnvFWrt74%3D Occurrence Handle12409522

    Article  CAS  PubMed  Google Scholar 

  132. A Patel AM Straight H Mann et al. (2002) ArticleTitleMatrix metalloproteinase (MMP) expression by differentiated thyroid carcinoma in children and adolescents J. Endocrinol. Invest. 25 403–408 Occurrence Handle1:CAS:528:DC%2BD38XksVCrsLk%3D Occurrence Handle12035934

    CAS  PubMed  Google Scholar 

  133. R Ramirez D Hsu A Patel et al. (2000) ArticleTitleOver-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma Clin. Endocrinol. (Oxf.) 53 635–644 Occurrence Handle10.1046/j.1365-2265.2000.01124.x Occurrence Handle1:CAS:528:DC%2BD3cXos1Oqt7s%3D

    Article  CAS  Google Scholar 

  134. R Ramirez D Hsu A Patel et al. (2000) ArticleTitleOver-expression of hepatocyte growth factor/scatter factor (HGF/SF) and the HGF/SF receptor (cMET) are associated with a high risk of metastasis and recurrence for children and young adults with papillary thyroid carcinoma Clin. Endocrinol. (Oxf.) 53 635–644 Occurrence Handle10.1046/j.1365-2265.2000.01124.x Occurrence Handle1:CAS:528:DC%2BD3cXos1Oqt7s%3D

    Article  CAS  Google Scholar 

  135. R Shah K Banks A Patel et al. (2002) ArticleTitleIntense expression of the b7-2 antigen presentation coactivator is an unfavorable prognostic indicator for differentiated thyroid carcinoma of children and adolescents J. Clin. Endocrinol. Metab. 87 4391–4397

    Google Scholar 

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  1. Department of Surgery , Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA

    Geoffrey B. Thompson M.D. & Ian D. Hay M.D.

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Thompson, G., Hay, I. Current Strategies for Surgical Management and Adjuvant Treatment of Childhood Papillary Thyroid Carcinoma. World J. Surg. 28, 1187–1198 (2004). https://doi.org/10.1007/s00268-004-7605-z

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