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Occurrence of Breast Mucinous Carcinoma After Autologous Fat Grating for Breast Augmentation

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Abstract

Autologous fat grafting is commonly performed in reconstructive breast surgery as well as in aesthetic breast augmentation surgery. Nevertheless, little is known about the interaction between fat grafts and cancer. A 36-year-old patient had undergone bilateral breast augmentation with autologous fat grafting. Two months after surgery, she perceived two small palpable indurations in the right breast. Nine months after the procedure, the lumps grew bigger and lumpectomy was performed. Histologic examination of the specimens showed mucinous carcinoma of the breast. This case raises once again the question about the possible links between breast cancer and fat grafts. The level of evidence is level V.

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References

  1. Delay E, Garson S, Tousson G, Sinna R (2009) Fat injection to the breast: technique, results, and indications based on 880 procedures over 10 years. Aesthet Surg J 29:360–376

    Article  PubMed  Google Scholar 

  2. Rigotti G, Marchi A, Stringhini P, Baroni G, Galiè M, Molino AM, Mercanti A, Micciolo R, Sbarbati A (2010) Determining the oncological risk of autologous lipoaspirate grafting for post-mastectomy breast reconstruction. Aesthet Plast Surg 34:475–480

    Article  Google Scholar 

  3. Mu DL, Luan J, Mu L, Xin MQ (2009) Breast augmentation by autologous fat injection grafting: management and clinical analysis of complications. Ann Plast Surg 63:124–127

    Article  CAS  PubMed  Google Scholar 

  4. Largo RD, Tchang LA, Mele V, Scherberich A, Harder Y, Wettstein R, Schaefer DJ (2014) Efficacy, safety and complications of autologous fat grafting to healthy breast tissue: a systematic review. J Plast Reconstr Aesthet Surg 67:437–448

    Article  PubMed  Google Scholar 

  5. Coleman SR, Saboeiro AP (2007) Fat grafting to the breast revisited: safety and efficacy. Plast Reconstr Surg 119:775–785 discussion 786–787

    Article  CAS  PubMed  Google Scholar 

  6. Kling RE, Mehrara BJ, Pusic AL, Young VL, Hume KM, Crotty CA, Rubin JP (2013) Trends in autologous fat grafting to the breast: a national survey of the american society of plastic surgeons. Plast Reconstr Surg 132:35–46

    Article  CAS  PubMed  Google Scholar 

  7. Krastev TK, Jonasse Y, Kon M (2013) Oncological safety of autologous lipoaspirate grafting in breast cancer patients: a systematic review. Ann Surg Oncol 20:111–119

    Article  CAS  PubMed  Google Scholar 

  8. Wang YY, Ren GS, Petit JY, Muller C (2013) Oncological risk after autologous lipoaspirate grafting in breast cancer patients: from the bench to the clinic and back. J Craniofac Surg 24:700–702

    Article  PubMed  Google Scholar 

  9. Petit JY, Rietjens M, Botteri E, Rotmensz N, Bertolini F, Curigliano G, Rey P, Garusi C, De Lorenzi F, Martella S, Manconi A, Barbieri B, Veronesi P, Intra M, Brambullo T, Gottardi A, Sommario M, Lomeo G, Iera M, Giovinazzo V, Lohsiriwat V (2013) Evaluation of fat grafting safety in patients with intraepithelial neoplasia: a matched-cohort study. Ann Oncol 24:1479–1484

    Article  CAS  PubMed  Google Scholar 

  10. Rowan BG, Gimble JM, Sheng M, Anbalagan M, Jones RK, Frazier TP, Asher M, Lacayo EA, Friedlander PL, Kutner R, Chiu ES (2014) Human adipose tissue-derived stromal/stem cells promote migration and early metastasis of triple negative breast cancer xenografts. PLoS One 9:e89595

    Article  PubMed Central  PubMed  Google Scholar 

  11. Crisostomo PR, Markel TA, Wang Y, Meldrum DR (2008) Surgically relevant aspects of stem cell paracrine effects. Surgery 143:577–581

    Article  PubMed Central  PubMed  Google Scholar 

  12. Martin-Padura I, Gregato G, Marighetti P, Mancuso P, Calleri A, Corsini C, Pruneri G, Manzotti M, Lohsiriwat V, Rietjens M, Petit JY, Bertolini F (2012) The white adipose tissue used in lipotransfer procedures is a rich reservoir of CD34+ progenitors able to promote cancer progression. Cancer Res 72:325–334

    Article  CAS  PubMed  Google Scholar 

  13. Schaffler A, Scholmerich J, Buechler C (2007) Mechanisms of disease: adipokines and breast cancer—endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Clin Pract Endocrinol Metab 3(4):345–354

    Article  PubMed  Google Scholar 

  14. Dieudonne MN, Bussiere M, Dos SE, Leneveu MC, Giudicelli Y, Pecquery R (2006) Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun 345:271–279

    Article  CAS  PubMed  Google Scholar 

  15. Lohsiriwat V, Curigliano G, Rietjens M, Goldhirsch A, Petit JY (2011) Autologous fat transplantation in patients with breast cancer: “silencing” or “fueling” cancer recurrence. Breast. 20:351–357

    Article  PubMed  Google Scholar 

  16. Delay E, Garson S, Tousson G, Sinna R (2009) Fat injection to the breast: technique, results, and indications based on 880 procedures over 10 years. Aesthet Surg J 29:360–376

    Article  PubMed  Google Scholar 

  17. Alharbi M, Garrido I, Vaysse C, Chavoin JP, Grolleau JL, Chaput B (2013) Latissimus dorsi flap invasion by ductal breast carcinoma after lipofilling. Plast Reconstr Surg Glob Open. 1:e68

    Article  PubMed Central  PubMed  Google Scholar 

  18. Pearl RA, Leedham SJ, Pacifico MD (2012) The safety of autologous fat transfer in breast cancer: lessons from stem cell biology. J Plast Reconstr Aesthet Surg 65:283–288

    Article  PubMed  Google Scholar 

  19. Fiaschetti V, Pistolese CA, Fornari M, Liberto V, Cama V, Gentile P, Floris M, Floris R, Cervelli V, Simonetti G (2013) Magnetic resonance imaging and ultrasound evaluation after breast autologous fat grafting combined with platelet-rich plasma. Plast Reconstr Surg 132:498e–509e

    Article  CAS  PubMed  Google Scholar 

  20. Vallejo A, Urban C, Zucca-Matthes G, Rietjens M (2013) Is there enough evidence to use lipofilling in breast cancer reconstruction. Plast Reconstr Surg 132:689e–691e

    Article  PubMed  Google Scholar 

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Correspondence to Fa-Cheng Li.

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Cheng, L., Han, XF., Zhang, C. et al. Occurrence of Breast Mucinous Carcinoma After Autologous Fat Grating for Breast Augmentation. Aesth Plast Surg 40, 102–105 (2016). https://doi.org/10.1007/s00266-015-0605-6

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  • DOI: https://doi.org/10.1007/s00266-015-0605-6

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