Original Article

Aesthetic Plastic Surgery

, Volume 32, Issue 1, pp 48-55

Open Access This content is freely available online to anyone, anywhere at any time.

Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells

  • Kotaro YoshimuraAffiliated withDepartment of Plastic Surgery, University of Tokyo School of Medicine Email author 
  • , Katsujiro SatoAffiliated withCellport Clinic Yokohama
  • , Noriyuki AoiAffiliated withDepartment of Plastic Surgery, University of Tokyo School of Medicine
  • , Masakazu KuritaAffiliated withDepartment of Plastic Surgery, Kyorin University School of Medicine
  • , Toshitsugu HirohiAffiliated withRitz Cosmetic Surgery Clinic Tokyo
  • , Kiyonori HariiAffiliated withDepartment of Plastic Surgery, Kyorin University School of Medicine

Abstract

Background

Lipoinjection is a promising treatment but has some problems, such as unpredictability and a low rate of graft survival due to partial necrosis.

Methods

To overcome the problems with lipoinjection, the authors developed a novel strategy known as cell-assisted lipotransfer (CAL). In CAL, autologous adipose-derived stem (stromal) cells (ASCs) are used in combination with lipoinjection. A stromal vascular fraction (SVF) containing ASCs is freshly isolated from half of the aspirated fat and recombined with the other half. This process converts relatively ASC-poor aspirated fat to ASC-rich fat. This report presents the findings for 40 patients who underwent CAL for cosmetic breast augmentation.

Results

Final breast volume showed augmentation by 100 to 200 ml after a mean fat amount of 270 ml was injected. Postoperative atrophy of injected fat was minimal and did not change substantially after 2 months. Cyst formation or microcalcification was detected in four patients. Almost all the patients were satisfied with the soft and natural-appearing augmentation.

Conclusions

The preliminary results suggest that CAL is effective and safe for soft tissue augmentation and superior to conventional lipoinjection. Additional study is necessary to evaluate the efficacy of this technique further.

Keywords

Adipose-derived stem/stromal cells Breast augmentation Cell therapy Lipoinjection Tissue engineering