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Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodelling

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Abstract

Thyroid-stimulating hormone (TSH) and follicle-stimulating hormone (FSH) have both been recently implicated in bone remodelling. Clinical evidence, as well as data from TSH receptor and thyroid hormone receptor knockout mice, suggest that TSH has a direct effect on skeletal homeostasis, although some data are conflicting. Recently, the exogenous administration of TSH has been shown to positively impact bone in oophrectomised rats. These data, along with their potential implications for the treatment of severe osteoporosis, are discussed.

Résumé

L’ATSH et la FSH sont impliquées de façon conjointe dans le remodelage osseux. Il est évident que sur le plan clinique et après analyse des données, la stimulation des récepteurs hormonaux de l’hormone thyroïdienne a un effet direct sur l’homéostasie osseuse. Récemment, il a été montré que l’utilisation d’hormones thyroïdiennes avait également un effet positif sur l’os des rats ovariectomisés. Toutes ces données et leurs conséquences thérapeutiques sont discutées dans les cas d’ostéoporoses sévères.

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Correspondence to Rebecca A. Sendak.

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All of the authors are employed by Genzyme Corporation, Framingham, MA.

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Sendak, R.A., Sampath, T.K. & McPherson, J.M. Newly reported roles of thyroid-stimulating hormone and follicle-stimulating hormone in bone remodelling. International Orthopaedics (SICO 31, 753–757 (2007). https://doi.org/10.1007/s00264-007-0417-7

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  • DOI: https://doi.org/10.1007/s00264-007-0417-7

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