Cancer Immunology, Immunotherapy

, 58:809

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008

Authors

    • Department of Molecular Cell Biology and Gene TherapyMax-Delbrück-Center of Molecular Medicine
    • Division of ImmunologyThe Netherlands Cancer Institute
Focussed Research Review

DOI: 10.1007/s00262-008-0649-4

Cite this article as:
Uckert, W. & Schumacher, T.N.M. Cancer Immunol Immunother (2009) 58: 809. doi:10.1007/s00262-008-0649-4

Abstract

The genetic introduction of T cell receptor genes into T cells has been developed over the past decade as a strategy to induce defined antigen-specific T cell immunity. With the potential value of TCR gene therapy well-established in murine models and the feasibility of infusion of TCR-modified autologous T cells shown in a first phase I trial, the next key step will be to transform TCR gene transfer from an experimental technique into a robust clinical strategy. In this review, we discuss the different properties of the TCR transgene and transgene cassette that can strongly affect both the efficacy and the safety of TCR gene transfer.

Keywords

T lymphocytesAdoptive T cell therapyTCR gene transferTCR engineering

Copyright information

© Springer-Verlag 2009