Focussed Research Review

Cancer Immunology, Immunotherapy

, Volume 58, Issue 5, pp 809-822

First online:

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008

  • Wolfgang UckertAffiliated withDepartment of Molecular Cell Biology and Gene Therapy, Max-Delbrück-Center of Molecular Medicine Email author 
  • , Ton N. M. SchumacherAffiliated withDivision of Immunology, The Netherlands Cancer Institute Email author 

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The genetic introduction of T cell receptor genes into T cells has been developed over the past decade as a strategy to induce defined antigen-specific T cell immunity. With the potential value of TCR gene therapy well-established in murine models and the feasibility of infusion of TCR-modified autologous T cells shown in a first phase I trial, the next key step will be to transform TCR gene transfer from an experimental technique into a robust clinical strategy. In this review, we discuss the different properties of the TCR transgene and transgene cassette that can strongly affect both the efficacy and the safety of TCR gene transfer.


T lymphocytes Adoptive T cell therapy TCR gene transfer TCR engineering