Abstract
The aim of this article is to provide Radiologists and Nuclear Medicine physicians the basic information required to understand how PET/MR scanners work, what are their limitations and how to evaluate their performance. It will cover the operational principles of standalone PET and MR imaging, as well as the technical challenges of creating a hybrid system and how they have been solved in the now commercially available scanners. Guidelines will be provided to interpret the main performance figures of hybrid PET/MR systems.
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Ratib O, Beyer T (2011) Whole-body hybrid PET/MRI: ready for clinical use? Eur J Nucl Med Mol Imaging 38:992–995
Schwenzer NF, Schmidt H, Claussen CD (2012) Whole-body MR/PET: applications in abdominal imaging. Abdom Imaging 37:20–28
Catana C, Drzezga A, Heiss WD, Rosen BR (2012) PET/MRI for neurologic applications. J Nucl Med 53:1916–1925
U.S. Department of Energy TOoBaER (2010) A vital legacy—biological and environmental research in the atomic age. Berkeley: Lawrence Berkeley National Laboratory
Cho ZH, Chan JK, Eriksson L (1976) Circular ring transverse axial positron camera for 3-dimensional reconstruction of radionuclides distribution. IEEE Trans Nucl Sci 23:613–622
Carr HY (1953) Free precession techniques in nuclear magnetic resonance. Cambridge: Harvard University
Damadian R, Goldsmith M, Minkoff L (1977) NMR in cancer: XVI. FONAR image of the live human body. Physiol Chem Phys 9:97–100, 108
Hamamatsu T (2006) Photomultiplier tubes—basics and applications, 3rd edn. Hamamatsy: Hamamatsu photonics K.K. Electron Tube Division
Spanoudaki VC, McElroy DP, Torres-Espallardo I, Ziegler SI (2008) Effect of temperature on the performance of proportional APD-based modules for gamma ray detection in positron emission tomography. IEEE Trans Nucl Sci 55:469–480
Del Guerra A, Belcari N, Giuseppina Bisogni M, et al. (2010) Advantages and pitfalls of the silicon photomultiplier (SiPM) as photodetector for the next generation of PET scanners. Nucl Instrum Methods Phys Res A 617:223–226
España S, Fraile LM, Herraiz JL, et al. (2010) Performance evaluation of SiPM photodetectors for PET imaging in the presence of magnetic fields. Nucl Instrum Methods Phys Res A 613:308–316
Zaidi H, et al. (2011) Design and performance evaluation of a whole-body ingenuity TF PET–MRI system. Phys Med Biol 56:3091
Veit-Haibach P, Kuhn FP, Wiesinger F, Delso G, von Schulthess G (2013) PET-MR imaging using a tri-modality PET/CT-MR system with a dedicated shuttle in clinical routine. Magn Reson Mater Phys 26:25–35
Shao Y, Cherry SR, Farahani K, et al. (1997) Development of a PET detector system compatible with MRI/NMR systems. IEEE Trans Nucl Sci 44:1167–1171
Shao Y, Cherry SR, Farahani K, et al. (1997) Simultaneous PET and MR imaging. Phys Med Biol 42:1965–1970
Slates RB, Farahani K, Shao Y, et al. (1999) A study of artefacts in simultaneous PET and MR imaging using a prototype MR compatible PET scanner. Phys Med Biol 44:2015–2027
Carson R, Herscovitch P, Daube-Witherspoon M (1998) Quantitative functional brain imaging with positron emission tomography. San Diego: Academic Press
Raylman RR, Majewski S, Lemieux SK, et al. (2006) Simultaneous MRI and PET imaging of a rat brain. Phys Med Biol 51:6371–6379
Schlyer D, Vaska P, Tomasi D, et al. (2007) A simultaneous PET/MRI scanner based on RatCAP in small animals. In: IEEE nuclear science symposium conference record, pp 3256–3259
Ravindranath B, Maramraju SH, Junnarkar SS, et al. (2008) A simultaneous PET/MRI breast scanner based on the RatCAP. In: IEEE nuclear science symposium conference record, pp 4650–4655
Catana C, Wu Y, Judenhofer MS, et al. (2006) Simultaneous acquisition of multislice PET and MR images: initial results with a MR-compatible PET scanner. J Nucl Med 47:1968–1976
Judenhofer MS, Wehrl HF, Newport DF, et al. (2008) Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med 14:459–465
Schlemmer H-P, Pichler B, Wienhard K, et al. (2007) Simultaneous MR/PET for brain imaging: first patient scans. J Nucl Med 48:45
Schlemmer H-PW, Pichler BJ, Schmand M, et al. (2008) Simultaneous MR/PET imaging of the human brain: feasibility study. Radiology 248:1028–1035
Delso G, Furst S, Jakoby B, et al. (2011) Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med 52:1914–1922
Levin C, Glover G, Deller T, et al. (2013) Prototype time-of-flight PET ring integrated with a 3T MRI system for simultaneous whole-body PET/MR imaging. J Nucl Med 54:148
Wagenknecht G, Kaiser HJ, Mottaghy FM, Herzog H (2013) MRI for attenuation correction in PET: methods and challenges. Magn Reson Mater Phys 26:99–113
Qian H, Shanbhag D, Kaushik S, et al. (2012) Whole-body PET/MR attenuation correction combining image segmentation, truncation completion and atlas-based skull segmentation. In: PET/MR and SPECT/MR: new paradigms for combined modalities in molecular imaging conference, Elba
Nuyts J, Bal G, Kehren F, et al. (2013) Completion of a truncated attenuation image from the attenuated PET emission data. IEEE Trans Med Imaging 32:237–246
Teuho J, Johansson J, Linden J, Saunavaara V, Tolvanen T, Teras M (2013) Quantitative bias in PET/MR from attenuation correction and reconstruction: a comparison with PET and PET/CT with an anatomical brain phantom and Hoffman brain phantom. In: 2013 IEEE nuclear science symposium and medical imaging conference (NSS/MIC), pp 1–8
Izquierdo-Garcia D, Sawiak S, Knesaurek K, et al. (2014) Comparison of MR-based attenuation correction and CT-based attenuation correction of whole-body PET/MR imaging. Eur J Nucl Med Mol Imaging 41:1574–1584
Aznar MC, Sersar R, Saabye J, et al. (2014) Whole-body PET/MRI: the effect of bone attenuation during MR-based attenuation correction in oncology imaging. Eur J Radiol 83:1177–1183
Delso G, Carl M, Wiesinger F, et al. (2014) Anatomic evaluation of 3-dimensional ultrashort-echo-time bone maps for PET/MR attenuation correction. J Nucl Med 55:780–785
NEMA NU 2-2012 (2012) Performance measurements of positron emission tomographs. Rosslyn: National Electrical Manufacturers Association
Boellaard R, O’Doherty MJ, Weber WA, et al. (2010) FDG PET and PET/CT: EANM procedure guidelines for tumour PET imaging: version 1.0. Eur J Nucl Med Mol Imaging 37:181–200
Kraus R, Delso G, Ziegler SI (2012) Simulation study of tissue-specific positron range correction for the new biograph mMR whole-body PET/MR system. IEEE Trans Nucl Sci 59:1900–1909
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Delso, G., ter Voert, E. & Veit-Haibach, P. How does PET/MR work? Basic physics for physicians. Abdom Imaging 40, 1352–1357 (2015). https://doi.org/10.1007/s00261-015-0437-5
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DOI: https://doi.org/10.1007/s00261-015-0437-5