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Correlation between [18F]FDG PET/CT and volume perfusion CT in primary tumours and mediastinal lymph nodes of non-small-cell lung cancer

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to investigate correlations between glucose metabolism as determined by [18F]FDG PET/CT and tumour perfusion as quantified by volume perfusion CT in primary tumours and mediastinal lymph nodes (MLN) of patients with non-small-cell lung cancer (NSCLC).

Methods

Enrolled in the study were 17 patients with NSCLC. [18F]FDG uptake was quantified in terms of SUVmax and SUVavg. Blood flow (BF), blood volume (BV) and flow extraction product (Ktrans) were determined as perfusion parameters. The correlations between the perfusion parameters and [18F]FDG uptake values were subsequently evaluated.

Results

For the primary tumours, no correlations were found between perfusion parameters and [18F]FDG uptake. In MLN, there were negative correlations between BF and SUVavg (r = −0.383), BV and SUVavg (r = −0.406), and BV and SUVmax (r = −0.377), but not between BF and SUVmax, Ktrans and SUVavg, or Ktrans and SUVmax. Additionally, in MLN with SUVmax >2.5 there were negative correlations between BF and SUVavg (r = −0.510), BV and SUVavg (r = −0.390), BF and SUVmax (r = −0.536), as well as BV and SUVmax (r = −0.346).

Conclusion

Perfusion and glucose metabolism seemed to be uncoupled in large primary tumours, but an inverse correlation was observed in MLN. This information may help improve therapy planning and response evaluation.

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Acknowledgments

We wish to thank our technicians Nicole Sachse, Astrid Schreiber, Henriette Heners and Simeon Winterstein for excellent assistance. Siemens Healthcare supported the study.

Conflicts of interest

Claus D. Claussen has a collaboration contract with Siemens Healthcare concerning the development of volume perfusion CT. Ernst Klotz is a Siemens Healthcare employee. All other authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Diagnostic and Interventional Radiology, Department of Radiology, Eberhard Karls University, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany

    Alexander W. Sauter, Daniel Spira, Maximilian Schulze, Christina Pfannenberg, Claus D. Claussen & Marius S. Horger

  2. Department of Oncology, Hematology, Immunology, Rheumatology and Pulmonology, Eberhard Karls University, Otfried-Müller-Str. 10, 72076, Tübingen, Germany

    Jürgen Hetzel

  3. Nuclear Medicine, Department of Radiology, Eberhard Karls University, Otfried-Müller-Str. 14, 72076, Tübingen, Germany

    Matthias Reimold

  4. Computed Tomography, Siemens Healthcare, Siemensstr. 1, 91301, Forchheim, Germany

    Ernst Klotz

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  1. Alexander W. Sauter
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Correspondence to Alexander W. Sauter.

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Sauter, A.W., Spira, D., Schulze, M. et al. Correlation between [18F]FDG PET/CT and volume perfusion CT in primary tumours and mediastinal lymph nodes of non-small-cell lung cancer. Eur J Nucl Med Mol Imaging 40, 677–684 (2013). https://doi.org/10.1007/s00259-012-2318-2

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  • DOI: https://doi.org/10.1007/s00259-012-2318-2

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