European Journal of Nuclear Medicine and Molecular Imaging

, Volume 39, Issue 11, pp 1767–1777

Posterior parietooccipital hypometabolism may differentiate mild cognitive impairment from dementia in Parkinson’s disease

  • David Garcia-Garcia
  • Pedro Clavero
  • Carmen Gasca Salas
  • Isabel Lamet
  • Javier Arbizu
  • Rafael Gonzalez-Redondo
  • Jose A. Obeso
  • Maria C. Rodriguez-Oroz
Original Article

DOI: 10.1007/s00259-012-2198-5

Cite this article as:
Garcia-Garcia, D., Clavero, P., Gasca Salas, C. et al. Eur J Nucl Med Mol Imaging (2012) 39: 1767. doi:10.1007/s00259-012-2198-5

Abstract

Purpose

Patients with Parkinson’s disease (PD) may have normal cognition, mild cognitive impairment (MCI) or dementia. We investigated differences in cerebral metabolism associated with these three cognitive states and the relationship between metabolism and cognitive dysfunction.

Methods

FDG PET and a battery of neuropsychological tests were used to study PD patients with dementia (n = 19), MCI (n = 28) and normal cognition (n = 21), and control subjects (n = 20). Regional glucose metabolism in patients and controls was analysed using statistical parametric mapping (SPM8) corrected for age, motor severity and depression. Correlations between the mini-mental state examination score and Z-score values of the different cognitive domains with respect to cerebral FDG uptake were assessed using SPM8.

Results

PD patients with MCI (PD-MCI patients) exhibited decreased FDG uptake in the frontal lobe, and to a lesser extent in parietal areas compared with cognitively normal patients. Patients with dementia showed reduced metabolism in the parietal, occipital and temporal areas and a less extensive reduction in the frontal lobe compared with PD-MCI patients, while widespread hypometabolism was seen in comparison with patients with normal cognition. PD-MCI patients exhibited reduced FDG uptake in the parietal and occipital lobes and in localized areas of the frontal and temporal lobes compared with controls, whereas patients with dementia showed a widespread reduction of cortical metabolism. Mini-mental state examination score correlated positively with metabolism in several lobes, executive function with metabolism in the parietooccipitotemporal junction and frontal lobe, memory with temporoparietal metabolism, visuospatial function with occipitoparietal and temporal metabolism, and language with frontal metabolism.

Conclusion

PD patients with MCI exhibited hypometabolism in several cortical regions compared with controls, and in the frontal and parietal regions compared with cognitively normal patients. Hypometabolism was higher in patients with dementia than in those with MCI, mainly in the posterior cortical areas where it was correlated with visuospatial, memory and executive functions.

Keywords

Parkinson’s diseaseMild cognitive impairmentPETCerebral metabolismDementia

Supplementary material

259_2012_2198_MOESM1_ESM.docx (87 kb)
ESM 1(DOCX 87 kb)
259_2012_2198_MOESM2_ESM.doc (68 kb)
ESM 2(DOC 68 kb)
259_2012_2198_MOESM3_ESM.doc (100 kb)
ESM 3(DOC 99 kb)

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • David Garcia-Garcia
    • 1
    • 2
  • Pedro Clavero
    • 1
  • Carmen Gasca Salas
    • 1
    • 2
  • Isabel Lamet
    • 1
  • Javier Arbizu
    • 3
  • Rafael Gonzalez-Redondo
    • 1
    • 2
  • Jose A. Obeso
    • 1
    • 2
  • Maria C. Rodriguez-Oroz
    • 1
    • 2
    • 4
    • 5
  1. 1.Neurosciences Area, CIMA, Department of Neurology and Neurosurgery, Clinica Universidad de NavarraUniversity of NavarraPamplonaSpain
  2. 2.Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED)MadridSpain
  3. 3.Department of Nuclear Medicine, ClínicaUniversity of NavarraPamplonaSpain
  4. 4.Department of Neurology and NeuroscienceUniversity Hospital Donostia, BioDonostia Research InstituteSan SebastianSpain
  5. 5.Ikerbasque, Basque Foundation for ScienceBilbaoSpain