Abstract
Objective
Determination of accurate histological grade impacts on management for soft tissue sarcomas (STSs). Although ultrasound-guided core needle biopsy (US-CNB) accurately establishes tumour subtype compared with surgical specimens, the concordance for tumour grade is uncertain. The aim of this study was to assess the concordance between US-CNB and surgical resection specimens for tumour grade in trunk and extremity STS.
Materials and methods
Retrospective review of consecutive patients presenting with extremity/trunk STS. Data collected included patient age, gender, lesion location, US-CNB diagnosis and grade, and surgical histology and grade. The histological diagnosis and tumour grade from US-CNB was compared with surgical resection histology.
Results
A total of 118 patients were included, 76 males and 42 females with a mean age of 54 years (range 10 months–90 years old). STS size ranged from 26 to 350 mm (mean 89.5 mm). All US-CNB procedures were performed with a 14G biopsy needle with a mean number of 5 passes. First US-CNB was diagnostic for STS in all patients, and provided adequate tissue for tumour grading in all but one patient. Histological tumour subtype on US-CNB matched surgical specimens in all cases, with 25 (21.2%) STS being low grade and 93 (78.8%) high grade. The concordance for tumour grade was 96.6%, with no difference between low- and high-grade STSs (p > 0.05). The 4 cases of mismatch were considered low grade on US-CNB, but subsequently high grade on surgical resection.
Conclusion
US-CNB of STS can reliably predict histological tumour grade compared with surgical resection specimens, thus allowing confident treatment decisions to be made.
Similar content being viewed by others
References
International Agency for Research on Cancer, World Health Organisation, International Academy of Pathology, Bridge JA, Hogendoorn PC, Fletcher C. WHO classification of tumours of soft tissue and bone. 4th ed: IARC; 2013.
Yao L, Nelson SD, Seeger LL, et al. Primary musculoskeletal neoplasms: effectiveness of core-needle biopsy. Radiology. 1999;212:682–6.
Colletti SM, Tranesh GA, Whetsell CR, et al. High diagnostic accuracy of core needle biopsy of soft tissue tumors: an institutional experience. Diagn Cytopathol. 2016;44:291–8.
Na J, Fang ZW, Zhao AL, et al. Diagnostic value of ultrasound-guided core needle biopsy for soft tissue tumors. Zhonghua Bing Li Xue Za Zhi. 2013;42:158–62.
Liu JC, Chiou HJ, Chen WM, et al. Sonographically guided core needle biopsy of soft tissue neoplasms. J Clin Ultrasound. 2004;32:294–8.
Torriani M, Etchebehere M, Amstalden E. Sonographically guided core needle biopsy of bone and soft tissue tumors. J Ultrasound Med. 2002;21:275–81.
Peer S, Freuis T, Loizides A, Gruber H. Ultrasound guided core needle biopsy of soft tissue tumors; a fool proof technique? Med Ultrason. 2011;13:187–94.
Lin X, Davion S, Bertsch EC, et al. Federation Nationale des Centers de Lutte Contre le Cancer grading of soft tissue sarcomas on needle core biopsies using surrogate markers. Hum Pathol. 2016;56:147–54.
Dangoor A, Seddon B, Gerrand C, et al. UK guidelines for the management of soft tissue sarcomas. Clin Sarcoma Res. 2016;6:20.
Fairweather M, Keung E, Raut CP. Neoadjuvant therapy for soft-tissue sarcomas. Oncology. 2016;30:99–106.
Le Grange F, Cassoni AM, Seddon BM. Tumour volume changes following pre-operative radiotherapy in borderline resectable limb and trunk soft tissue sarcoma. Eur J Surg Oncol. 2014;40:394–401.
Trojani M, Contesso G, Coindre JM, et al. Soft tissue sarcomas of adults: study of pathological prognostic variables and definition of histopathological grading system. Int J Cancer. 1984;33:37–42.
Zhao F, Ahlawat S, Farahani SJ, et al. Can MR imaging be used to predict tumor grade in soft-tissue sarcoma? Radiology. 2014;272:192–201.
Chhabra A, Ashikyan O, Slepicka C, et al. Conventional MR and diffusion-weighted imaging of musculoskeletal soft tissue malignancy: correlation with histologic grading. Eur Radiol. 2019;29:4485–94.
Chatterjee S. Artefacts in histopathology. J Oral Maxillofac Pathol. 2014;18(Suppl 1):S111–6.
Coindre JM. Grading of soft tissue sarcomas – review and update. Arch Pathol Lab Med. 2006;130:1448–53.
Kim SY, Chung HW. Small musculoskeletal soft-tissue lesions: US-guided core needle biopsy—comparative study of diagnostic yields according to lesion size. Radiology. 2016;278:156–63.
Khoo M, Pressney I, Hargunani R, et al. Small, superficial, indeterminate soft-tissue lesions as suspected sarcomas: is primary excision biopsy suitable? Skelet Radiol. 2017;46:919–24.
Nishio J. Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors. J Biomed Biotechnol. 2011;2011:524067.
Dei Tos AP. Liposarcomas: diagnostic pitfalls and new insights. Histopathology. 2014;64:38–52.
Ferguson KB, McGlynn J, Jane M, et al. Outcome of image-guided biopsies: retrospective review of the West of Scotland musculoskeletal oncology service. Surgeon. 2016;14:87–90.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that there are no conflicts of interest.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Tan, A., Rajakulasingam, R. & Saifuddin, A. Diagnostic concordance between ultrasound-guided core needle biopsy and surgical resection specimens for histological grading of extremity and trunk soft tissue sarcoma. Skeletal Radiol 50, 43–50 (2021). https://doi.org/10.1007/s00256-020-03496-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00256-020-03496-8