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Application of conditionally replicating adenoviruses in tumor early diagnosis technology, gene-radiation therapy and chemotherapy

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Abstract

Conditionally replicating adenoviruses (CRAds), or known as replication-selective adenoviruses, were discovered as oncolytic gene vectors several years ago. They have a strong ability of scavenging tumor and lesser toxicity to normal tissue. CRAds not only have a tumor-killing ability but also can combine with gene therapy, radiotherapy, and chemotherapy to induce tumor cell apoptosis. In this paper, we review the structure of CRAds and CRAd vectors and summarize the current application of CRAds in tumor detection as well as in radiotherapy and suicide gene-mediating chemotherapy. We also propose further research strategies that can improve the application value of CRAds, including enhancing tumor destruction effect, further reducing toxic effect, reducing immunogenicity, constructing CRAds that can target tumor stem cells, and trying to use mesenchymal stem cells (MSCs) as the carriers for oncolytic adenoviruses. As their importance to cancer diagnosis, gene-radiation, and chemotherapy, CRAds may play a considerable role in clinical diagnosis and various cancer treatments in the future.

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Acknowledgments

This study was supported by grants from the Natural Science foundation of China (NO.31670952) and also thanks the support from the Chongqing Engineering Laboratory in Vascular Implants, the National “111 Plan” Base (B06023) and the Public Experiment Center of State Bio-industrial Base (Chongqing), China.

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  1. Key Laboratory for Bio-rheological Science and Technology of Ministry of Education, Chongqing University, Chongqing, China

    Shun Li, Mengting Ou, Guixue Wang & Liling Tang

  2. Bioengineering College of Chongqing University, Chongqing, 400044, China

    Shun Li, Mengting Ou, Guixue Wang & Liling Tang

  3. State and Local Joint Engineering Laboratory for Vascular Implants, Chongqing, China

    Shun Li, Mengting Ou, Guixue Wang & Liling Tang

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  1. Shun Li
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Li, S., Ou, M., Wang, G. et al. Application of conditionally replicating adenoviruses in tumor early diagnosis technology, gene-radiation therapy and chemotherapy. Appl Microbiol Biotechnol 100, 8325–8335 (2016). https://doi.org/10.1007/s00253-016-7806-z

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