Applied Microbiology and Biotechnology

, Volume 92, Issue 1, pp 45-53

First online:

Impact of the Penicillium chrysogenum genome on industrial production of metabolites

  • Marco Alexander van den BergAffiliated withDSM Biotechnology Center (699-0310) Email author 

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The genome sequence of Penicillium chrysogenum has initiated a range of fundamental studies, deciphering the genetic secrets of the industrial penicillin producer. More than 60 years of classical strain improvement has resulted in major but delicate rebalancing of the intracellular metabolism leading to the impressive penicillin titres of the current production strains. Several leads for further improvement are being followed up, including the use of P. chrysogenum as a cell factory for other products than β-lactam antibiotics.


Penicillium chrysogenum Genomics Antibiotics Metabolites Industrial production