Abstract
3-Hydroxypropionaldehyde (3-HPA) forms, together with HPA-hydrate and HPA-dimer, a dynamic, multi-component system (HPA system) used in food preservation, as a precursor for many modern chemicals such as acrolein, acrylic acid, and 1,3-propanediol (1,3-PDO), and for polymer production. 3-HPA can be obtained both through traditional chemistry and bacterial fermentation. To date, 3-HPA has been produced from petrochemical resources as an intermediate in 1,3-PDO production. In vivo, glycerol is converted in one enzymatic step into 3-HPA. The 3-HPA-producing Lactobacillus reuteri is used as a probiotic in the health care of humans and animals. The biotechnological production of 3-HPA from renewable resources is desirable both for use of 3-HPA in foods and for the production of bulk chemicals. The main challenge will be the efficient production and recovery of pure 3-HPA.
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Acknowledgements
We thank Prof. Dr. Puhan for critical advice. We thank Prof. Hsing-Wen Sung, Mr. Donald B. Appleby (Procter & Gamble Chemicals), and Mr. Valéry Desroches (HB International S.A.), for kindly providing data for the figures presented in this work. We thank Mr. Heinz Trogemann (Stockhausen GmbH & Co. KG) and Mrs. Albrecht (Celanese AG) for providing information on the price of acrylic acid, and Joseph W. Carroll (DuPont Co.) for helpful discussions. The authors would like to offer special thanks to Annemieke Ijpenberg and Janice Sych for critical review.
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Vollenweider, S., Lacroix, C. 3-Hydroxypropionaldehyde: applications and perspectives of biotechnological production. Appl Microbiol Biotechnol 64, 16–27 (2004). https://doi.org/10.1007/s00253-003-1497-y
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DOI: https://doi.org/10.1007/s00253-003-1497-y