Applied Microbiology and Biotechnology

, Volume 58, Issue 6, pp 695–703

Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics

  •  R. Heath
  •  S. White
  •  C. Rock
Mini-Review

DOI: 10.1007/s00253-001-0918-z

Cite this article as:
Heath, R., White, S. & Rock, C. Appl Microbiol Biotechnol (2002) 58: 695. doi:10.1007/s00253-001-0918-z

Abstract.

Fatty acid biosynthesis is an emerging target for the development of novel antibacterial chemotherapeutics. The dissociated bacterial system is substantially different from the large, multifunctional protein of mammals, and many possibilities exist for type-selective drugs. Several compounds, both synthetic and natural, target bacterial fatty acid synthesis. Three compounds target the FabI enoyl-ACP reductase step; isoniazid, a clinically used antituberculosis drug, triclosan, a widely used consumer antimicrobial, and diazaborines. In addition, cerulenin and thiolactomycin, two fungal products, inhibit the FabH, FabB and FabF condensation enzymes. Finally, the synthetic reaction intermediates BP1 and decynoyl-N-acetyl cysteamine inhibit the acetyl-CoA carboxylase and dehydratase isomerase steps, respectively. The mechanisms of action of these compounds, as well as the potential development of new drugs targeted against this pathway, are discussed.

Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  •  R. Heath
    • 1
  •  S. White
    • 2
  •  C. Rock
    • 1
  1. 1.Protein Science Division, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis TN 38105, USA
  2. 2.Department of Structural Biology, St. Jude Children's Research Hospital, Memphis TN 38105, USA
  3. 3.Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA