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Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis

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Abstract

Co-existence of bronchial asthma (BA) and tuberculosis (TB) is extremely uncommon (dystropic). We assume that this is caused by the interplay between genes involved into specific pathophysiological pathways that arrest simultaneous manifestation of BA and TB. Identification of common and specific genes may be important to determine the molecular genetic mechanisms leading to rare co-occurrence of these diseases and may contribute to the identification of susceptibility genes for each of these dystropic diseases. To address the issue, we propose a new methodological strategy that is based on reconstruction of associative networks that represent molecular relationships between proteins/genes associated with BA and TB, thus facilitating a better understanding of the biological context of antagonistic relationships between the diseases. The results of our study revealed a number of proteins/genes important for the development of both BA and TB.

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Acknowledgments

This work was financially supported by the President’s Grant for the Leading Scientific Schools of Russian Federation (5096.2014.4) and grant from the Federal Target Program Scientific and scientific-pedagogical personnel of innovative Russia for 2009–2013 years (contract number 8156) to E.Y.B., L.A.K., M.B.F., and V.P.P. and a project VI.61.1.2 and MES to E.S.T., P.S.D., V.A.I., and N.A.K.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Laboratory of Population Genetics, Research Institute of Medical Genetics, Siberian Branch of Russian Academy of Medical Sciences, Nabereznaya Ushaiki str. 10, Tomsk, Russian Federation, 634050

    Elena Yu. Bragina, Maxim B. Freidin, Lada A. Koneva & Valery P. Puzyrev

  2. Laboratory of Computational Proteomics, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentiev ave. 10, Novosibirsk, Russian Federation, 630090

    Evgeny S. Tiys, Pavel S. Demenkov, Vladimir A. Ivanisenko & Nikolay A. Kolchanov

  3. Department of Information Biology, Novosibirsk State University, Pirogova Str. 2, Novosibirsk, Russian Federation, 630090

    Evgeny S. Tiys, Pavel S. Demenkov & Vladimir A. Ivanisenko

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  1. Elena Yu. Bragina
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  2. Evgeny S. Tiys
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  3. Maxim B. Freidin
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  4. Lada A. Koneva
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  5. Pavel S. Demenkov
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  6. Vladimir A. Ivanisenko
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  7. Nikolay A. Kolchanov
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  8. Valery P. Puzyrev
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Correspondence to Elena Yu. Bragina.

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Bragina, E.Y., Tiys, E.S., Freidin, M.B. et al. Insights into pathophysiology of dystropy through the analysis of gene networks: an example of bronchial asthma and tuberculosis. Immunogenetics 66, 457–465 (2014). https://doi.org/10.1007/s00251-014-0786-1

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