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On the reliability of quantitation of biological effect in drug–interceptor–DNA systems

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Abstract

Relative insensitivity of theoretical estimation of biological effect in drug–interceptor–DNA systems is found with respect to variation of parameters of quasiphysiological conditions. The “inertness” of the biological response, in part, justifies the use of parameters of intermolecular interaction, derived from independent physicochemical experiments, in estimation of relative biological effect in the theory of interceptor/protector action.

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Anonymous referees are thanked for fruitful comments.

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Correspondence to Anatoly S. Buchelnikov.

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Buchelnikov, A.S., Evstigneev, V.P., Rodríguez Oropeza, L.E. et al. On the reliability of quantitation of biological effect in drug–interceptor–DNA systems. Eur Biophys J 42, 315–319 (2013). https://doi.org/10.1007/s00249-013-0893-1

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  • DOI: https://doi.org/10.1007/s00249-013-0893-1

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