Pediatric Radiology

, Volume 36, Issue 5, pp 415–420

The potential of digital X-ray radiogrammetry (DXR) in the assessment of osteopenia in children with chronic inflammatory bowel disease

  • Hans-Joachim Mentzel
  • Joerg Blume
  • Joachim Boettcher
  • Gabriele Lehmann
  • Diana Tuchscherer
  • Alexander Pfeil
  • Anika Kramer
  • Ansgar Malich
  • Eberhard Kauf
  • Gert Hein
  • Werner A. Kaiser
Original Article

DOI: 10.1007/s00247-005-0093-y

Cite this article as:
Mentzel, HJ., Blume, J., Boettcher, J. et al. Pediatr Radiol (2006) 36: 415. doi:10.1007/s00247-005-0093-y

Abstract

Background

Loss of bone mass is a known complication of chronic inflammatory bowel disease (IBD) in children. The gold standard in the evaluation of bone mineral density (BMD) is dual energy X-ray absorptiometry (DXA).

Objective

In this preliminary study we evaluated digital X-ray radiogrammetry (DXR) which estimates BMD (DXR-BMD) from hand radiographs in children with IBD.

Materials and methods

A total of 26 children with IBD (10 girls, 16 boys; age range 10–18 years) underwent DXR for the calculation of DXR-BMD and metacarpal index (DXR-MCI) using the Pronosco X-posure system. The results were compared with a local reference database and correlated with the results of DXA.

Results

DXR-BMD was 0.36–0.56 g/cm2 (median 0.46 g/cm2) in Crohn disease patients and 0.38–0.63 g/cm2 (median 0.48 g/cm2) in ulcerative colitis patients. DXR-MCI was 0.29–0.49 in Crohn disease patients and 0.28–0.53 in ulcerative colitis patients. The Z-scores were reduced to <−1 SD in five Crohn disease patients and in six ulcerative colitis patients. The coefficients (r) for the correlations between DXR-BMD and DXA-BMD were 0.78 for the lumbar spine and 0.61 for the proximal femur (P<0.01), and between DXR-MCI and DXA-BMD were 0.78 for the lumbar spine and 0.51 for the proximal femur (P<0.01).

Conclusions

DXR seems to be able to estimate cortical osteopenia in children with chronic IBD. The DXR results showed a positive correlation with DXA results.

Keywords

Inflammatory bowel diseaseOsteopeniaDigital X-ray radiogrammetryBone mineral densityMetacarpal indexDual energy X-ray absorptiometry

Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Hans-Joachim Mentzel
    • 1
  • Joerg Blume
    • 2
  • Joachim Boettcher
    • 1
  • Gabriele Lehmann
    • 3
  • Diana Tuchscherer
    • 1
  • Alexander Pfeil
    • 1
  • Anika Kramer
    • 1
  • Ansgar Malich
    • 1
  • Eberhard Kauf
    • 2
  • Gert Hein
    • 3
  • Werner A. Kaiser
    • 1
  1. 1.Department of Pediatric Radiology, Institute of Diagnostic and Interventional RadiologyFriedrich-Schiller-University JenaJenaGermany
  2. 2.Department of Gastroenterology, Clinic of PediatricsFriedrich-Schiller-University JenaJenaGermany
  3. 3.Department of Rheumatology and Osteology, Clinic of Internal MedicineFriedrich-Schiller-University JenaJenaGermany