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Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases

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Abstract

To determine reference values for fetal heart biometric parameters using the spatiotemporal image correlation (STIC) M mode and their applicability in congenital heart diseases (CHDs). A cross-sectional prospective study was conducted with 300 singleton pregnancies between 20 and 33 + 6 weeks of gestation. Right ventricular wall thickness (RVWT), interventricular septum thickness (IVST), and left ventricular wall thickness (LVWT) were measured off-line using the STIC-M mode with the cursor perpendicular to the interventricular septum. Polynomial regressions adjusted with the coefficient of determination (R 2) were performed. The curves were applied to 14 fetuses with structural CHD. For the reproducibility calculations, the concordance correlation coefficient (CCC) was used. The mean RVWT, IVST, and LVWT were 0.34 ± 0.09 cm, 0.28 ± 0.09 cm, and 0.30 ± 0.07 cm, respectively. There was correlation between RVWT, IVST, and LVWT and gestational age (GA): RVWT = −0.002 + 0.013 × GA (R 2 = 0.33), IVST = −0.011 + 0.011 × GA (R 2 = 0.25), and LVWT = 0.056 + 0.009 × GA (R 2 = 0.26). RVWT, IVST, and LVWT were altered (<5th or >95th percentile) in 5/14, 5/14, and 7/14 of the fetuses with CHD, respectively. For RVWT, IVST, and LVWT, intra-observer (CCC = 0.86, 0.85, and 0.87, respectively) and inter-observer (CCC = 0.86, 0.86, and 0.86, respectively) reproducibility were good/moderate. The reference ranges determined for fetal heart biometric parameters using STIC-M had good intra- and inter-observer reproducibility and were applicable to fetuses with CHD.

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Authors and Affiliations

  1. Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), Rua Belchior de Azevedo, 156 apto. 111 Torre Vitoria, São Paulo, SP, CEP 05089–030, Brazil

    Giselle Darahem Tedesco, Marilim de Souza Bezerra, Fernanda Silveira Bello Barros, Luciano Marcondes Machado Nardozza, Milene Carvalho Carrilho, Antonio Fernandes Moron, Liliam Cristine Rolo & Edward Araujo Júnior

  2. Department of Obstetrics and Gynecology, Ribeirão Preto Medical School, University of São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil

    Wellington P. Martins

  3. Department of Maternal and Child, Federal University of Ceará (UFC), Fortaleza, CE, Brazil

    Francisco Herlânio Costa Carvalho

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  1. Giselle Darahem Tedesco
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  2. Marilim de Souza Bezerra
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  3. Fernanda Silveira Bello Barros
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  4. Wellington P. Martins
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  5. Luciano Marcondes Machado Nardozza
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  6. Milene Carvalho Carrilho
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  7. Antonio Fernandes Moron
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  8. Francisco Herlânio Costa Carvalho
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  9. Liliam Cristine Rolo
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  10. Edward Araujo Júnior
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Correspondence to Edward Araujo Júnior.

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Tedesco, G.D., de Souza Bezerra, M., Barros, F.S.B. et al. Reference Ranges of Fetal Cardiac Biometric Parameters Using Three-Dimensional Ultrasound with Spatiotemporal Image Correlation M Mode and Their Applicability in Congenital Heart Diseases. Pediatr Cardiol 38, 271–279 (2017). https://doi.org/10.1007/s00246-016-1509-1

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  • DOI: https://doi.org/10.1007/s00246-016-1509-1

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