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Transcatheter Closure of Perimembranous Ventricular Septal Defects with Left Ventricular to Right Atrial Shunt

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Abstract

During the development of so-called aneurysmal transformation of perimembranous ventricular septal defects (pmVSD), tricuspid valve (TV) morphology and function may be altered resulting in left ventricular (LV) to right atrial (RA) shunting. The feasibility and outcome of interventional closure of these pmVSD has not been investigated so far. Interventional closure of pmVSD associated with mild to moderate LV-to-RA shunt was performed in four patients (aged 6.5–12.5 years). pmVSD were closed under fluoroscopic guidance by establishing an arteriovenous wire loop via a femoral artery and advancing the delivery sheath from a femoral vein. Before device release (or withdrawal if necessary), residual shunting across the device and TV valve function was investigated by transthoracic echocardiography and LV angiography. pmVSD sizes of 4, 5.5, 8 and 8.5 mm were closed with a 4/4 and 6/6 Amplatzer duct occluder II and an 8- and 10-mm Amplatzer muscular VSD occluder device, respectively. There were no or only minor residual postinterventional LV-to-RA shunts. No atrioventricular blocks were observed during a mean follow-up of 12.5 months (range 6.5–17 months). Transthoracic echocardiography indicated that the elimination of the VSD jet pushing the antero-superior TV leaflet open is the key mechanism for LV-to-RA shunt reduction after transcatheter pmVSD closure. Interventional closure in pmVSD associated with mild to moderate indirect LV-to-RA shunting is feasible and results in significant reduction in or elimination of LV-to-RA shunting.

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Pediatric Heart Center Giessen, University Children’s Hospital, Feulgenstr. 10-12, 35392, Giessen, Germany

    Gunter Kerst, Axel Moysich, Christian Apitz, Heiner Latus & Dietmar Schranz

  2. Cardiac Morphology Unit, Royal Brompton Hospital, Imperial College London, London, UK

    Siew Yen Ho

Authors
  1. Gunter Kerst
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  2. Axel Moysich
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  3. Siew Yen Ho
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  4. Christian Apitz
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  5. Heiner Latus
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  6. Dietmar Schranz
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Corresponding author

Correspondence to Gunter Kerst.

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Video 1, 2. Tricuspid valve morphology and function before (1) and after (2) VSD closure by a 4/4 ADO II (patient #2), evaluated by transthoracic echocardiography (modified parasternal short axis view) with simultaneous color Doppler interrogation. (mp4 codec). Supplementary material 1 (MP4 1992 kb)

Supplementary material 2 (MP4 2283 kb)

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Kerst, G., Moysich, A., Ho, S.Y. et al. Transcatheter Closure of Perimembranous Ventricular Septal Defects with Left Ventricular to Right Atrial Shunt. Pediatr Cardiol 36, 1386–1392 (2015). https://doi.org/10.1007/s00246-015-1170-0

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  • DOI: https://doi.org/10.1007/s00246-015-1170-0

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