Abstract
Few studies have examined the role that small for gestational age (SGA) status plays in postoperative outcomes for low-birth-weight (LBW) infants with congenital heart disease (CHD). This study aimed to examine the effect of SGA status, gestational and chronologic age, and weight on differences in morbidities and mortalities during the immediate postoperative hospitalization period. The charts of infants with CHD weighing less than 2.5 kg who underwent operative repair during the neonatal period between 2004 and 2011 were reviewed. Infants with an isolated patent ductus arteriosus were excluded from the study. Data on hospital morbidities and mortality before discharge were collected. The study identified 136 LBW infants with a diagnosis of CHD. Among the 74 infants who underwent surgery and had complete chart records, the SGA infants had a higher gestational age at birth (36.8 vs. 32.3 weeks; p < 0.0001). The SGA and non-SGA infants did not differ in terms of survival to discharge or immediate postoperative outcomes. A lower weight at surgery was significantly associated with an increased risk of postoperative infection. In contradistinction, an older postnatal age at surgery was associated with an increased risk of preoperative infection (p < 0.0001). Additionally, lower gestational age at birth was associated with home oxygen use, higher tracheostomy rates, and discharge with a gastrostomy tube. Small for gestational age status played no protective role in the outcome for LBW infants after primary surgery for CHD. A weight of 2.4 kg or greater at the time of surgery was associated with lower rates of postoperative infections. Greater duration of time between birth and surgery was associated with a greater risk of preoperative infection. A gestational age of 32 weeks or more at birth was associated with decreased morbidities, which could influence obstetric management.
Similar content being viewed by others
References
Ades A, Johnson BA, Berger S (2005) Management of low-birth-weight infants with congenital heart disease. Clin Perinatol 32:999–1015
Andrews RE, Simpson SJ, Sharland GK, Sullivan ID, Yates RW (2006) Outcome following preterm delivery of infants antenatally diagnosed with congenital heart disease. J Pediatr 148:213–216
Beeby P, Jeffery H (1992) Risk factors for necrotizing enterocolitis: the influence of gestational age. Arch Dis Child 67:432–435
Bove T, Francois K, De Groote K, Suys B, De Wolf D, Verhaaren H, Matthys D, Moerman A, Poelaert J, Vanhaesebroeck P, Van Nooten G (2004) Outcome analysis of major cardiac operations in low-weight neonates. Ann Thorac Surg 78:181–187
Burch P, Cowley C, Holubkov R, Null D, Lambert L, Kouretas P, Hawkins J (2009) Coarctation repair in neonates and young infants: is small size or low weight still a risk factor? J Thorac Cardiovasc Surg 138:537–552
De Jesus L, Pappas A, Shankaran S, Li L, Das A, Bell E, Stoll B, Laptook A, Walsh M, Hale E, Newman N, Bara R, Higgins R (2013) Outcomes of small for gestational age infants born at < 27 weeks’ gestation. J Pediatr 163:55–60
Dimmick S, Walker K, Badawi N, Halliday R, Cooper S, Nicholson I, Sherwood M, Chard R, Hawker R, Lau K, Jones O, Grant P, Sholler G, Winlaw D (2007) Outcomes following surgery for congenital heart disease in low-birth-weight infants. J Paediatr Child Health 43:370–375
Dorfman A, Levine J, Colan S, Geva T (2005) Accuracy of echocardiography in low-birth-weight infants with congenital heart disease. Pediatrics 115:102–107
Gaynor JW, Wernovsky G, Jarvik G, Bernbaum J, Gerdes M, Zackai E, Nord A, Clancy R, Nicolson S, Spray T (2007) Patient characteristics are important determinants of neurodevelopmental outcome at one year of age after neonatal and infant cardiac surgery. J Thorac Cardiovasc Surg 133:1344–1353
Gortner L, Wauer R, Stock G, Reiter H, Reiss I, Jorch G, Hentschel R, Hieronimi G (2005) Neonatal outcome in small for gestational age infants: do they really better? J Perinat Med 27:484–489
Hehir D, Dominguez T, Ballweg J, Ravishankar C, Marino B, Bird G, Nicholson S, Spray T, Gaynor J, Tabbutt S (2008) Risk factors for interstage death after stage 1 reconstruction of hypoplastic left heart syndrome and variants. J Thorac Cardiovasc Surg 136:94–99
Karamlou T, Bernasconi A, Jaeggi E, Alhabshan F, Williams W, Van Arsdell G, Coles J, Caldarone C (2009) Factors associated with arch reintervention and growth of the aortic arch after coarctation repair in neonates weighing less than 2.5 kg. J Thorac Cardiovasc Surg 137:1163–1167
Kecskes Z, Cartwright DW (2002) Poor outcome of very-low-birth-weight babies with serious congenital heart disease. Arch Dis Child Fetal Neonatal Ed 87:F31–F33
Kramer H, Trampisch H, Rammos S, Giese A (1990) Birth weight of children with congenital heart disease. Eur J Pediatr 149:752–757
Lechner E, Wiesinger-Eidenberger G, Weissensteiner M, Hofer A, Tulzer G, Sames-Dolzer E, Mair R (2009) Open heart surgery in premature and low-birth-weight infants: a single-centre experience. Eur J Cardiothorac Surg 36:986–991
Malik S, Cleves M, Zhao W, Correa A, Hobbs CA (2007) Association between congenital heart defects and small for gestational age. Pediatrics 119:e976–e982
McIntire D, Bloom S, Casey B, Leveno K (1999) Birth weight in relation to morbidity and mortality among newborn infants. N Engl J Med 340:1234–1238
Natarajan G, Anne S, Aggarwal S (2011) Outcomes of congenital heart disease in late preterm infants: double jeopardy? Acta Paediatr 100:1104–1107
Oppido G, Napoleone CP, Formigari R, Gabbieri D, Pacini D, Frascaroli G, Gargiulo G (2004) Outcome of cardiac surgery in low-birth-weight and premature infants. Eur J Cardiothorac Surg 26:44–53
Pappas A, Shankaran S, Hensen N, Bell E, Stoll B, Laptook A, Walsh M, Das A, Bara R, Hale E, Newman N, Boghossian N, Murray J, Cotton C, Adams-Chapman I, Hamrick S, Higgins R (2012) Outcome of extremely preterm infants (< 1,000 g) with congenital heart defects from the National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Cardiol 33:1415–1426
Reiss I, Landmann E, Heckmann M, Misselwitz B, Gortner L (2003) Increased risk of bronchopulmonary dysplasia and increased mortality in very preterm infants being small for gestational age. Arch Gynecol Obstet 269:40–44
Rossi A, Seiden H, Sadeghi A, Nguyen K, Quintana C, Gross R, Griepp R (1998) The outcome of cardiac operations in infants weight two kilograms or less. J Thorac Cardiovasc Surg 116:28–35
Seo DM, Park JJ, Yun TJ, Kim YH, Ko JK, Park IS, Jhang WK (2011) The outcome of open heart surgery for congenital heart disease in infants with low body weight less than 2,500 g. Pediatr Cardiol 32:578–584
Shepard C, Kochilas L, Rosengart R, Brearley A, Bryant R, Moller J, St. Louis J (2010) Repair of major congenital cardiac defects in low-birth-weight infants: is delay warranted? J Thorac Cardiovasc Surg 140:1104–1109
Acknowledgments
This publication was supported by NIH/NCRR SC-CTSI grant no. UL1 RR031986. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wei, D., Azen, C., Bhombal, S. et al. Congenital Heart Disease in Low-Birth-Weight Infants: Effects of Small for Gestational Age (SGA) Status and Maturity on Postoperative Outcomes. Pediatr Cardiol 36, 1–7 (2015). https://doi.org/10.1007/s00246-014-0954-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00246-014-0954-y