Abstract
During the last 20 years, there has been a shift away from combined heart–lung transplantation (HLT) in favor of bilateral lung transplantation. This paradigm shift allowed for the donor heart to be transplanted to another patient. However, HLT remains to be the definitive surgical treatment for certain congenital heart disorders and Eisenmenger’s syndrome. With a growing population of adult patients with congenital heart disease, there remains a need for HLT. This article provides a perspective on the past and the future of HLT.
Similar content being viewed by others
References
Anyanwu AC, Banner NR, Radley-Smith R, Khaghani A, Yacoub MH (2002) Long-term results of cardiac transplantation from live donors: the domino heart transplant. J Heart Lung Transplant 21(9):971–975
Anyanwu AC, Banner NR, Mitchell AG, Khaghani A, Yacoub MH (2003) Low incidence and severity of transplant-associated coronary artery disease in heart transplants from live donors. J Heart Lung Transplant 22(3):281–286
Astor TL, Galantowicz M, Phillips A, Davis JT, Hoffman TM (2007) Domino heart transplantation involving infants. Am J Transplant 7(11):2626–2629
Aurora P, Edwards LB, Kucheryavaya AY, Christie JD, Dobbels F, Kirk R et al (2010) The registry of the international society for heart and lung transplantation: thirteenth official pediatric lung and heart–lung transplantation report-2010. J Heart Lung Transplant 29(10):1129–1141
Baldwin JC, Oyer PE, Stinson EB, Starnes VA, Billingham ME, Shumway NE (1987) Comparison of cardiac rejection in heart and heart–lung transplantation. J Heart Transplant 6(6):352–356
Baumgartner WA, Traill TA, Cameron DE, Fonger JD, Birenbaum IB, Reitz BA (1989) Unique aspects of heart and lung transplantation exhibited in the ‘domino-donor’ operation. JAMA 261(21):3121–3125
Benden C, Harpur-Sinclair O, Ranasinghe AS, Hartley JC, Elliott MJ, Aurora P (2007) Surveillance bronchoscopy in children during the first year after lung transplantation: is it worth it? Thorax 62(1):57–61
Benden C, Aurora P, Edwards LB, Kucheryavaya AY, Christie JD, Dobbels F et al (2011) The registry of the international society for heart and lung transplantation: fourteenth pediatric lung and heart–lung transplantation report-2011. J Heart Lung Transplant 30(10):1123–1132
Bentley TS, Hanson SG (2011) 2011 U.S. organ and tissue transplant cost estimates and discussion. Available at http://publications.milliman.com/research/health-rr/pdfs/2011-us-organ-tissue.pdf. Accessed 15 Feb 2012
Birks EJ, Yacoub MH, Anyanwu A, Smith RR, Banner NR, Khaghani A (2004) Transplantation using hearts from primary pulmonary hypertensive donors for recipients with a high pulmonary vascular resistance. J Heart Lung Transplant 23(12):1339–1344
Boehler A, Vogt P, Zollinger A, Weder W, Speich R (1996) Prospective study of the value of transbronchial lung biopsy after lung transplantation. Eur Respir J 9(4):658–662
Burch M, Aurora P (2004) Current status of paediatric heart, lung, and heart–lung transplantation. Arch Dis Child 89(4):386–389
Burton CM, Iversen M, Scheike T, Carlsen J, Andersen CB (2008) Minimal acute cellular rejection remains prevalent up to 2 years after lung transplantation: a retrospective analysis of 2697 transbronchial biopsies. Transplantation 85(4):547–553
Cavarocchi NC, Badellino M (1989) Heart/heart–lung transplantation. The domino procedure. Ann Thorac Surg 48(1):130–133
Choong CK, Sweet SC, Guthrie TJ, Mendeloff EN, Haddad FJ, Schuler P et al (2005) Repair of congenital heart lesions combined with lung transplantation for the treatment of severe pulmonary hypertension: a 13-year experience. J Thorac Cardiovasc Surg 129(3):661–669
Christie JD, Edwards LB, Kucheryavaya AY, Aurora P, Dobbels F, Kirk R et al (2010) The registry of the international society for heart and lung transplantation: twenty-seventh official adult lung and heart–lung transplant report-2010. J Heart Lung Transplant 29(10):1104–1118
Christie JD, Edwards LB, Kucheryavaya AY, Benden C, Dobbels F, Kirk R et al (2011) The registry of the international society for heart and lung transplantation: twenty-eighth adult lung and heart–lung transplant report-2011. J Heart Lung Transplant 30(10):1104–1122
Cochrane AD, Smith JA, Esmore DS (1991) The “domino-donor” operation in heart and lung transplantation. Med J Aust 155(9):589–593
Faro A, Visner G (2004) The use of multiple transbronchial biopsies as the standard approach to evaluate lung allograft rejection. Pediatr Transplant 8(4):322–328
Ganesh JS, Rogers CA, Bonser RS, Banner NR, Steering Group of the UK Cardiothoracic Transplant Audit (2005) Outcome of heart–lung and bilateral sequential lung transplantation for cystic fibrosis: a UK national study. Eur Respir J 25(6):964–969
Gatzoulis MA, Alonso-Gonzalez R, Beghetti M (2009) Pulmonary arterial hypertension in paediatric and adult patients with congenital heart disease. Eur Respir Rev 18(113):154–161
Girgis RE, Reichenspurner H, Robbins RC, Reitz BA, Theodore J (1995) The utility of annual surveillance bronchoscopy in heart–lung transplant recipients. Transplantation 60(12):1458–1461
Glanville AR (2010) Bronchoscopic monitoring after lung transplantation. Semin Respir Crit Care Med 31(2):208–221
Glanville AR, Imoto E, Baldwin JC, Billingham ME, Theodore J, Robin ED (1987) The role of right ventricular endomyocardial biopsy in the long-term management of heart–lung transplant recipients. J Heart Transplant 6(6):357–361
Gorlitzer M, Ankersmit HJ, Wollenek G, Wisser W, Wieselthaler G, Haisjackl M et al (2002) Backtable ventricular and atrial septal defect repair of an Eisenmenger allograft with concomitant domino heart transplantation. J Thorac Cardiovasc Surg 123(2):374–376
Griffith BP, Hardesty RL, Trento A, Bahnson HT (1985) Asynchronous rejection of heart and lungs following cardiopulmonary transplantation. Ann Thorac Surg 40(5):488–493
Guilinger RA, Paradis IL, Dauber JH, Yousem SA, Williams PA, Keenan RJ et al (1995) The importance of bronchoscopy with transbronchial biopsy and bronchoalveolar lavage in the management of lung transplant recipients. Am J Respir Crit Care Med 152(6 Pt 1):2037–2043
Hayes D Jr, Baker PB, Astor TL, Preston TJ, Kirkby S, Galantowicz M et al Aggressive coronary artery vasculopathy after combined heart–lung transplantation. Congenit Heart Dis (in press)
Hoeper MM, Hamm M, Schäfers HJ, Haverich A, Wagner TO (1992) Evaluation of lung function during pulmonary rejection and infection in heart–lung transplant patients. Hannover Lung Transplant Group. Chest 102(3):864–870
Hopkins PM, Aboyoun CL, Chhajed PN, Malouf MA, Plit ML, Rainer SP et al (2002) Prospective analysis of 1,235 transbronchial lung biopsies in lung transplant recipients. J Heart Lung Transplant 21(10):1062–1067
International Society for Heart and Lung Transplantation (2003) Registries—Heart/Lung Registries. Available at http://www.ishlt.org/registries/heartLungRegistry.asp. Accessed 15 Feb 2012
Keenan RJ, Bruzzone P, Paradis IL, Yousem SA, Dauber JH, Stuart RS et al (1991) Similarity of pulmonary rejection patterns among heart–lung and double-lung transplant recipients. Transplantation 51(1):176–180
Kesten S, Chamberlain D, Maurer J (1996) Yield of surveillance transbronchial biopsies performed beyond two years after lung transplantation. J Heart Lung Transplant 15(4):384–388
Lehto JT, Koskinen PK, Anttila VJ, Lautenschlager I, Lemström K, Sipponen J et al (2005) Bronchoscopy in the diagnosis and surveillance of respiratory infections in lung and heart–lung transplant recipients. Transpl Int 18(5):562–571
Lowell JA, Taranto SE, Singer GG, Miller SB, Ghalib R, Caldwell C et al (1997) Transplant recipients as organ donors: the domino transplant. Transplant Proc 29(8):3392–3393
Luckraz H, Charman SC, Parameshwar J, Tsui SS, Dunning J, Wallwork J, Large SR (2004) Are non-brain stem-dead cardiac donors acceptable donors? J Heart Lung Transplant 23(3):330–333
Madden BP, Hodson ME, Tsang V, Radley-Smith R, Khaghani A, Yacoub MY (1992) Intermediate-term results of heart–lung transplantation for cystic fibrosis. Lancet 339(8809):1583–1587
McGlothlin D, De Marco T (2011) Transplantation in adults with congenital heart disease. Prog Cardiovasc Dis 53(4):312–323
McWilliams TJ, Williams TJ, Whitford HM, Snell GI (2008) Surveillance bronchoscopy in lung transplant recipients: risk versus benefit. J Heart Lung Transplant 27(11):1203–1209
Milano CA, Buchan K, Perreas K, Wallwork J (1999) Thoracic organ transplantation at Papworth Hospital. Clin Transpl 273–280. PMID 11038646
Oaks TE, Aravot D, Dennis C, Wells FC, Large SR, Wallwork J (1994) Domino heart transplantation: the Papworth experience. J Heart Lung Transplant 13(3):433–4337
Pinderski LJ, Kirklin JK, McGiffin D, Brown R, Naftel DC, Young KR Jr et al (2005) Multi-organ transplantation: Is there a protective effect against acute and chronic rejection? J Heart Lung Transplant 24(11):1828–1833
Raffa GM, Pellegrini C, Viganò M (2010) Domino heart transplantation: long-term outcome of recipients and their living donors: Single center experience. Transplant Proc 42(9):3688–3693
Reitz BA, Wallwork JL, Hunt SA, Pennock JL, Billingham ME, Oyer PE et al (1982) heart–lung transplantation: Successful therapy for patients with pulmonary vascular disease. N Engl J Med 306(10):557–564
Rose M, Strange G, King I, Arnup S, Vidmar S, Kermeen F, et al. (2011) Congenital heart disease associated pulmonary arterial hypertension: Preliminary results from a novel registry. Intern Med J. doi:10.1111/j.1445-5994.2011.02708.x
Scott JP, Fradet G, Smyth RL, Solis E, Higenbottam TW, Wallwork J (1990) Management following heart and lung transplantation: Five years experience. Eur J Cardiothorac Surg 4(4):197–200 discussion 201
Scott JP, Higenbottam TW, Smyth RL, Whitehead B, Helms P, Fradet G et al (1990) Transbronchial biopsies in children after heart–lung transplantation. Pediatrics 86(5):698–702
Smith JA, Roberts M, McNeil K, Sharples LD, Schofield PM, Large SR et al (1996) Excellent outcome of cardiac transplantation using domino donor hearts. Eur J Cardiothorac Surg 10(8):628–633
Starnes VA, Theodore J, Oyer PE, Billingham ME, Sibley RK, Berry G et al (1989) Evaluation of heart–lung transplant recipients with prospective, serial transbronchial biopsies and pulmonary function studies. J Thorac Cardiovasc Surg 98(5 Pt 1):683–690
Stehlik J, Edwards LB, Kucheryavaya AY, Aurora P, Christie JD, Kirk R et al (2010) The registry of the international society for heart and lung transplantation: twenty-seventh official adult heart transplant report-2010. Heart Lung Transplant 29(10):1089–1103
Stoica SC, Satchithananda DK, Atkinson C, Charman S, Goddard M, Large SR (2003) Heat shock protein, inducible nitric oxide synthase and apoptotic markers in the acute phase of human cardiac transplantation. Eur J Cardiothorac Surg 24(6):932–939
Swanson SJ, Mentzer SJ, Reilly JJ, Bueno R, Lukanich JM, Jaklitsch MT et al (2000) Surveillance transbronchial lung biopsies: Implication for survival after lung transplantation. J Thorac Cardiovasc Surg 119(1):27–37
Trulock EP, Ettinger NA, Brunt EM, Pasque MK, Kaiser LR, Cooper JD (1992) The role of transbronchial lung biopsy in the treatment of lung transplant recipients. An analysis of 200 consecutive procedures. Chest 102(4):1049–1054
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hayes, D., Galantowicz, M. & Hoffman, T.M. Combined Heart–Lung Transplantation: A Perspective on the Past and the Future. Pediatr Cardiol 34, 207–212 (2013). https://doi.org/10.1007/s00246-012-0397-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00246-012-0397-2