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The use of adjunctive hemostatic agents in tubeless percutaneous nephrolithotomy: a meta-analysis

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Abstract

The purpose of the study was to systematically review and assess the safety and efficacy of hemostatic agents in tubeless percutaneous nephrolithotomy. Original studies on the use of hemostatic agents in tubeless percutaneous nephrolithotomy (PCNL) from January 2001 to March 2014 were searched in Ovid, Science Direct, Pubmed, and Embase by two independent reviewers. A drop in hemoglobin (Hb), analgesic requirements, length of hospital stay, and necessity for blood transfusions were compared using Review Manager 5.2. The methods were done according to the Cochrane Handbook for interventional systematic reviews and written based on the PRISMA Statement. Seven studies involving 351 patients met the inclusion criteria for the meta-analysis. The baseline characteristics were comparable in all of the studies. The results showed that the length of hospital stay was less in the experimental group than in the control group (P < 0.05). There were no significant statistical differences in terms of a drop in Hb, analgesic requirements, and the necessity for a blood transfusion between the two groups (P > 0.05). The meta-analysis indicated that the hemostatic agents in tubeless PCNL were not expected to be unsafe or mandatory, but that they were expected to be expensive. We concluded that hemostatic agents might not be necessary in tubeless PCNL.

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Conflict of interest

We declare that we have no financial, consultant, institutional and personal relationships with other people or organizations that can inappropriately influence our work and lead to bias or a conflict of interest, there is no professional or other personal interest of any nature or kind in any product, service or company that could be construed as influencing the position presented in, or the review of the manuscript entitled ‘The use of adjunctive hemostatic agents in tubeless percutaneous nephrolithotomy:a meta-analysis’ by Jiawu Wang et al.

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Authors and Affiliations

  1. Department of Urology, The General Hospital of Chongqing Steel Company, 400081, Chongqing, China

    Jiawu Wang, Guangzhong Tan, Bo Yang, Wenkai Chen & Dan Tan

  2. Department of General Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Chengyao Zhang

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  1. Jiawu Wang
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  2. Chengyao Zhang
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  3. Guangzhong Tan
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Correspondence to Jiawu Wang.

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Wang, J., Zhang, C., Tan, G. et al. The use of adjunctive hemostatic agents in tubeless percutaneous nephrolithotomy: a meta-analysis. Urolithiasis 42, 509–517 (2014). https://doi.org/10.1007/s00240-014-0717-5

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