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Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata

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Abstract

Urinary type calcium hydrogen phosphate dihydrate (CHPD) or Brushite crystals were grown by the single diffusion gel technique in silica hydro-gels. The gel framework acts as a three dimensional crucible in which the crystal nuclei are delicately held in the position of their formation and nutrients are supplied for their growth. This technique can be utilized as a simplified screening model to study the growth and dissolution of urinary stones in vitro. The action of the putatively litholytic medicinal plants Tribulus terrestris and Bergenia ligulata on the growth of CHPD crystals was studied . The effects of artificial reference urine (ARU) and human urine (HU), along with the plant extracts, are also reported. Attempts were made to understand the role of these inhibitors on urinary crystal formation. HU, ARU, extracts of B. ligulata and T. terrestris exhibit appreciable amounts of inhibition, but B.ligulata and T.terrestris with ARU and HU do not show inhibition at all.

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Acknowledgements

V.S.J. andM.J.J. are thankful to Prof. K.N. Iyer, Head, Physics Department, Saurashtra University, and the former Head Prof. B.S. Shah for their interest. The authors are thankful to the Department of Biotechnology, Government of India, New Delhi, for financial support. They also thank the President, Bhartiya Vidya Bhavan, for encouraging scientific research in Ayurveda. The authors are thankful to Dr. Vrinda S. Thaker, Bio-science Department, Saurashtra University, Rajkot, for her important suggestions.

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Authors and Affiliations

  1. Crystal Growth Laboratory, Physics Department, Saurashtra University, Rajkot 360, India

    Vimal S. Joshi, Bharat B. Parekh & Mihir J. Joshi

  2. Bhavan’s Swami Prakashananda Ayurveda Research Centre, Juhu, Mumbai 400 049, India

    Ashok D. B. Vaidya

  3. Shri. R.K. Parikh Arts and Science College, Petlad 388 450, Dist. Anand., Gujarat, India

    Vimal S. Joshi

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  1. Vimal S. Joshi
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Joshi, V.S., Parekh, B.B., Joshi, M.J. et al. Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata. Urol Res 33, 80–86 (2005). https://doi.org/10.1007/s00240-004-0450-6

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  • DOI: https://doi.org/10.1007/s00240-004-0450-6

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