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Craniofacial CT findings of Gorham–Stout disease and generalized lymphatic anomaly

  • Head and Neck Radiology
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Abstract

Introduction

The present study aimed to assess the craniofacial CT imaging features for differentiating between Gorham–Stout disease (GSD) and generalized lymphatic anomaly (GLA).

Methods

Seven patients with GSD and four patients with GLA were included in this study. All patients underwent CT examinations that encompassed the craniofacial bones. The presence, distribution, and type of craniofacial osteolysis were assessed. The clinical symptoms that were associated with craniofacial osteolysis were also reviewed.

Results

Craniofacial osteolysis including cranial osteolysis was seen in four of seven (57 %) patients with GSD and in three of four (75 %) patients with GLA. Facial osteolysis was seen in two (29 %) patients with GSD, but this was not observed in patients with GLA. Among patients with craniofacial osteolysis, those with GSD showed diffuse involvement, whereas those with GLA showed multifocal involvement. The craniofacial osteolysis of GSD could be classified into three patterns: medullary involvement, thinning bone, and disappearing bone. The clinical symptoms of craniofacial osteolysis were observed in all patients with GSD but were not present in patients with GLA.

Conclusion

Craniofacial involvement was observed in both groups. The craniofacial osteolysis of GSD showed diffuse involvement with clinical symptoms, whereas that of GLA showed multifocal involvement without clinical symptoms.

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Authors and Affiliations

  1. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Hiroki Kato & Masayuki Matsuo

  2. Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan

    Michio Ozeki & Toshiyuki Fukao

Authors
  1. Hiroki Kato
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  2. Michio Ozeki
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  3. Toshiyuki Fukao
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  4. Masayuki Matsuo
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Corresponding author

Correspondence to Hiroki Kato.

Ethics declarations

We declare that all human and animal studies have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

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Kato, H., Ozeki, M., Fukao, T. et al. Craniofacial CT findings of Gorham–Stout disease and generalized lymphatic anomaly. Neuroradiology 58, 801–806 (2016). https://doi.org/10.1007/s00234-016-1691-0

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  • DOI: https://doi.org/10.1007/s00234-016-1691-0

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