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Effectiveness of four different clinical fMRI paradigms for preoperative regional determination of language lateralization in patients with brain tumors

  • Functional Neuroradiology
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Abstract

Introduction

Blood oxygen level-dependent functional magnetic resonance imaging (fMRI) has demonstrated its capability to provide comparable results to gold standard intracarotid sodium amobarbital (Wada) testing for preoperative determination of language hemispheric dominance. However, thus far, no consensus has been established regarding which fMRI paradigms are the most effective for the determination of hemispheric language lateralization in specific categories of patients and specific regions of interest (ROIs).

Methods

Forty-one brain tumor patients who performed four different language tasks—rhyming (R), silent word generation (SWG) sentence completion, and sentence listening comprehension (LC)—for presurgical language mapping by fMRI were included in this study. A statistical threshold-independent lateralization index (LI) was calculated and compared among the paradigms in four different ROIs for language activation: functional Broca’s (BA) and Wernicke’s areas (WA) as well as larger anatomically defined expressive (EA) and receptive (RA) areas.

Results

The two expressive paradigms evaluated in this study are very good lateralizing tasks in expressive language areas; specifically, a significantly higher mean LI value was noted for SWG (0.36 ± 0.25) compared to LC (0.16 ± 0.24, p = 0.009) and for R (0.40 ± 0.22) compared to LC (0.16 ± 0.24, p = 0.001) in BA. SWG LI (0.28 ± 0.19) was higher than LC LI (0.12 ± 0.16, p = 0.01) also in EA. No significant differences in LI were found among these paradigms in WA or RA.

Conclusions

SWG and R are sufficient for the determination of lateralization in expressive language areas, whereas new semantic or receptive paradigms need to be designed for an improved assessment of lateralization in receptive language areas.

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Acknowledgements

This work is partially and indirectly funded by Siemens Medical Solutions (grant no. 39154). Siemens played no role in the study design, data collection and analysis, or preparation of the manuscript.

Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine & The Johns Hopkins Hospital, 600 N. Wolfe Street, Phipps B-100, Baltimore, MD, 21287, USA

    Domenico Zacà, Gerard Deib & Jay J Pillai

  2. Department of Radiology, The University of Vermont School of Medicine/Fletcher Allen Healthcare, 111 Colchester Ave., Burlington, VT, 05401, USA

    Joshua P. Nickerson

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  1. Domenico Zacà
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Correspondence to Jay J Pillai.

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Zacà, D., Nickerson, J.P., Deib, G. et al. Effectiveness of four different clinical fMRI paradigms for preoperative regional determination of language lateralization in patients with brain tumors. Neuroradiology 54, 1015–1025 (2012). https://doi.org/10.1007/s00234-012-1056-2

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  • DOI: https://doi.org/10.1007/s00234-012-1056-2

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