, Volume 53, Issue 1 Supplement, pp 185-189
Date: 24 Aug 2011

Osteoporosis

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access
This is an excerpt from the content

Introduction

Osteoporosis is a skeletal disorder resulting from an heterogeneous group of abnormal processes leading to low bone mass and bone microarchitectural disruption, jeopardizing the bone structural integrity and increasing bone fragility and risk of fracture [1].

Osteoporosis courses with normal levels serum of calcium and phosphorus. The osteoporotic bone is normally mineralized, but there is a disruption of its normal microarchitecture, trabecular bone loss and increased cortical porosity [1].

Low bone mass may result from increased bone resorption or reduced bone formation during remodelling, being commonly accepted that the first has a higher impact on osteoporosis development [1]. After an initial increase in bone resorption, leading to a decrease in bone mass, the compensatory bone formation fails due to the presence of microstructural changes. The mechanisms causing the microarchitectural disruption are not clear, but may include increased bone turnover and microfractures